Prophylactic effect of flavanol rich preparation metabolites in promoting resilience to a mouse model of social stress.

Translational Psychiatry
Jun WangGiulio M Pasinetti

Abstract

Major depressive disorder (MDD) is a leading cause of disability, and there is an urgent need for new therapeutics. Stress-mediated induction of pro-inflammation in the periphery contributes to depression-like behaviors both in humans and in experimental models. Inflammatory cytokine interleukin-6 (IL-6) has emerged as a potential therapeutic target. Our studies demonstrated that metabolism of flavanol rich cocoa preparation (FRP) led to the accumulation of select phenolic acids that may contribute to its anti-inflammatory activity. Using a repeated social defeat stress (RSDS) model of depression, we showed that oral administration of FRP attenuates susceptibility to RSDS-mediated depression, supporting the further development of FRP as a novel therapeutic for the treatment of stress disorders and anxiety in humans.

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Citations

Nov 23, 2021·Molecular Nutrition & Food Research·Hiba N RajhaMarvin Edeas
Jan 7, 2022·Metabolomics : Official Journal of the Metabolomic Society·George E JaskiwCurtis J Donskey

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Methods Mentioned

BETA
density-gradient centrifugation
ELISA

Software Mentioned

DataAnalysis
Prism Stat
Ethovision
GraphPad
Bruker Daltonics

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