Prophylactic effect of papaverine prolonged-release pellets on cerebral vasospasm in dogs

Neurosurgery
K ShiokawaK Takakura

Abstract

A drug delivery system using copoly(lactic/glycolic acid) was developed for the intracranial administration of papaverine. A rod-shaped implant prepared by a heat compression method was tested to determine its efficacy in preventing cerebral vasospasm in dogs. Sixteen dogs were randomly assigned to one of two groups, i.e., placebo or papaverine. Control angiography was performed, followed by right craniectomy and the induction of subarachnoid hemorrhage by the placement of a clot in the Sylvian fissure. Two pellets, containing either 25 mg of papaverine or no papaverine, were placed in the cistern. In in vitro studies, 56% of the actual papaverine loading was released in the first 4 days and 78% within 8 days. On Day 7, angiography was repeated and the animals were killed. A similar experiment using low-dose pellets containing 5 mg of papaverine, half of which was released within 7 days, was performed with 16 mongrel dogs. There were significant differences between the papaverine- and placebo-treated groups in the reductions of vessel diameters of the internal carotid, middle cerebral, and anterior cerebral arteries on the clot side. The mean concentration of papaverine in the clot was 4.5 x 10(-4) mol/L. The low-dose pellet fa...Continue Reading

References

Dec 1, 1992·Journal of Neurosurgery·N F KassellW S Cail
Nov 1, 1992·Pharmaceutical Research·P K GuptaP P DeLuca
Jan 1, 1973·Journal of Neurosurgery·M OgataW M Lougheed
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Citations

Nov 6, 2003·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Krzysztof MorawskiBrenda L Lonsbury-Martin
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·Hidetoshi KasuyaTomokastu Hori
Mar 2, 2006·Biological & Pharmaceutical Bulletin·Tatsuhiro IshidaHiroshi Kiwada
Aug 7, 2004·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tatsuhiro Ishida
Dec 26, 2008·Neurological Research·Elena TitovaJiping Tang
Dec 4, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jae Hoon KimJae-Min Kim
Jul 24, 2013·Stroke Research and Treatment·Fatima A Sehba, Ryszard M Pluta
Feb 7, 2001·Stroke; a Journal of Cerebral Circulation·P VajkoczyP Schmiedek

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