Prophylactic feeding with immune-enhanced diet ameliorates chemoradiation-induced gastrointestinal injury in rats

International Journal of Radiation Biology
Beste M AtasoyBerrak Ç Yeğen

Abstract

To investigate the protective effect of immune-enhanced diet (IED) on chemoradiation-induced injury of the gastrointestinal mucosa. Forty-eight Sprague-Dawley rats were divided into control (C, n=6), irradiation (IR, n=14), fluoropyrimidine (5-FU, n=14)-treated, IR + 5-FU (n=14)-treated groups. Half of each irradiated and/or 5-FU-treated groups were previously fed with IED containing arginine, omega-3-fatty acids and RNA fragments, while the other half were fed a standard rat diet (SD) for eight days before the induction of IR or injection of 5-FU. In IR groups, whole abdominal irradiation (11 Gy) was performed with 6 MV photons. In the 5-FU groups, fluoropyrimidine (100 mg/kg) was administered intraperitoneally 30 min prior to irradiation. All animals were sacrificed on the 4th day of IR or 5-FU injection. Bacterial colony counts in the ceca and mesenteric lymph nodes of IED-fed rats, which have received either 5-FU and/or irradiation were significantly lower than the corresponding SD-fed groups. Morphometric results revealed that gastric, ileal and colonic injuries were less in IED-treated IR or IR + 5-FU + IED groups, as compared to SD-fed groups. However, IED did not alter DNA fragmentation ratios. Prophylactic feeding of I...Continue Reading

References

Jan 1, 1990·Free Radical Biology & Medicine·K Asayama, K Kato
Apr 1, 1990·American Journal of Surgery·E A DeitchR D Specian
Feb 1, 1989·The Journal of Surgical Research·G Guzman-SteinJ P Delaney
Dec 1, 1984·Cancer·M W MulhollandJ P Delaney
Aug 1, 1997·The American Journal of Physiology·C S Potten
Jul 1, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J W DenhamS Wright
Jun 6, 2000·Critical Reviews in Oncology/hematology·G Nitenberg, B Raynard
Oct 31, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D KiliçA Dursun
Mar 23, 2002·Microbes and Infection·Andrew S Neish
Jun 14, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·James W Denham, Martin Hauer-Jensen
Jul 20, 2002·The Journal of Surgical Research·Diane RhodenR Neal Garrison
Jun 6, 2003·The Journal of Surgical Research·Paul J MathesonR Neal Garrison
Aug 12, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·C LinardD Mathe
Dec 24, 2003·Clinical Oncology : a Journal of the Royal College of Radiologists·P RavascoM E Camilo
Apr 27, 2004·Cancer·Stephen T SonisUNKNOWN International Society for Oral Oncology
May 27, 2004·British Journal of Cancer·C McGoughH J N Andreyev
Feb 1, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Núria FarrerasJosé A González
Feb 3, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paula RavascoMaria Ermelinda Camilo
Jan 27, 2006·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Eric Van Cutsem, Jann Arends
Feb 7, 2006·Nutrition·Seher DemirerSercin Karahüseyinoglu
Apr 8, 2006·American Journal of Clinical Oncology·Diclehan UnsalYucel Pak
May 16, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J ArendsUNKNOWN ESPEN (European Society for Parenteral and Enteral Nutrition)
Nov 11, 2006·Seminars in Oncology Nursing·Vanna M Dest
Mar 21, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Mónica María Marín CaroClaude Pichard
Jun 26, 2007·World Journal of Gastroenterology : WJG·Meritxell Molla, Julian Panes
Sep 19, 2007·World Journal of Surgery·Hiroya TakeuchiSumio Matsumoto
Sep 2, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L WedlakeH J N Andreyev
Oct 28, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anne CappJames W Denham

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Citations

Sep 26, 2020·Frontiers in Cellular and Infection Microbiology·Panida SittipoYun Kyung Lee
Jun 6, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Süleyman OyanAyse Dağlı Değerli

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