Prophylactic glycopyrrolate reduces hypotensive responses in elderly patients during spinal anesthesia: a randomized controlled trial

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Jinyoung HwangJin Huh

Abstract

Hypotension during spinal anesthesia is a serious complication in elderly patients. We evaluated the effect of glycopyrrolate on hypotensive responses in elderly patients undergoing spinal anesthesia. Sixty-six patients older than 60 yr of age scheduled for elective surgery with spinal anesthesia were included in the study. They received either glycopyrrolate 0.2 mg (group G) or normal saline (group C) intramuscularly 15 min before spinal anesthesia. The following outcomes were evaluated after the induction of spinal anesthesia: the incidence of hypotension and bradycardia, the ephedrine requirement, mean arterial pressure, heart rate, and the incidence of nausea and vomiting. Twenty-three of 33 (70.0%) patients in group C experienced hypotension compared with nine of 33 (27.3%) patients in group G (difference = 42.7%; 95% confidence interval [CI]: 18.4 to 60.2; P = 0.001). The median [interquartile range] amount of ephedrine required was 5 [0-15] mg in group C compared with 0 [0-5] mg in group G (difference = 5.0 mg; 95% CI: 2.7 to 7.3; P = 0.001). Nine (27.3%) patients in group C experienced nausea and vomiting compared with 2 (6.1%) in group G (difference = 21.2%; 95% CI: 3.0 to 38.7; P = 0.044). Three (9.1%) patients in gro...Continue Reading

References

Jun 1, 1990·British Journal of Anaesthesia·T M Ali-MelkkiläE Iisalo
Aug 1, 1989·Acta Anaesthesiologica Scandinavica·T Ali-MelkkiläJ Kanto
May 1, 1972·Anesthesia and Analgesia·C H KlingenmaierR Watson
Dec 1, 1983·Anaesthesia·R K Mirakhur, J W Dundee
Apr 1, 1995·British Journal of Anaesthesia·L A CritchleyT G Short
May 1, 1995·British Journal of Anaesthesia·J E SternloR Sandin
Sep 1, 1996·Journal of Clinical Anesthesia·C A BernsteinD Ritter
Feb 24, 2009·Journal of Clinical Anesthesia·Christian S MeyhoffLars S Rasmussen

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