Prophylactic hepatic arterial infusion chemotherapy for the prevention of liver metastasis in patients with colon carcinoma: a randomized control trial

Cancer
Sotaro SadahiroChieko Murayama

Abstract

The liver is the most frequent site of recurrence after curative resection in patients with colon carcinoma. For liver metastasis, a high response rate can be achieved with hepatic arterial infusion (HAI) chemotherapy. In the current study, the authors administered 5-fluorouracil (5-FU) as adjuvant chemotherapy by HAI to patients with colon carcinoma without liver metastases and studied its effects on recurrence in the liver and survival. A total of 316 patients with preoperative Stage II or Stage III colon carcinoma (according to the 1997 revision of the International Union Against Cancer TNM staging system) were randomly assigned to receive surgery plus 3-week continuous HAI of 5-FU or surgery alone. There were 305 eligible patients, of whom the 119 patients assigned to the HAI arm actually received 5-FU. The primary endpoint was disease-free survival, whereas the secondary endpoints were overall survival and liver metastasis-free survival. Analysis was by intent to treat. There were no significant differences noted in morbidity between the two treatment arms. During the follow-up period (median, 59.0 months), the incidence of liver metastasis was significantly decreased in the HAI arm whereas there were no significant differ...Continue Reading

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Citations

Mar 6, 2010·International Journal of Colorectal Disease·Shin FujitaMasayuki Ohue
Jun 29, 2007·Journal of the National Cancer Institute·Cornelis J A PuntJean-Yves Douillard
Jan 22, 2005·Annual Review of Medicine·David J BentremLeslie H Blumgart
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Feb 22, 2007·AJR. American Journal of Roentgenology·Sakae NagaokaMichio Sata
Jul 25, 2008·Clinical Colorectal Cancer·Derek G PowerNancy E Kemeny
Nov 27, 2004·Journal of Surgical Oncology·Masashi WatanabeKazuo Kobayashi
Jun 27, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Dirk M Bernold, Frank A Sinicrope
Nov 16, 2010·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Sun Young ChoiKwang-Hun Lee
Jul 23, 2008·The Cochrane Database of Systematic Reviews·Alvaro FigueredoSom Mukherjee
Jul 1, 2015·Hepatic Oncology·Alexandre DoussotMichael I D'Angelica

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