Prophylactic intravesical instillation of mitomycin C and cytosine arabinoside for prevention of recurrent bladder tumors following surgery for upper urinary tract tumors: a prospective randomized study

International Journal of Urology : Official Journal of the Japanese Urological Association
N SakamotoKyushu University Urological Oncology Group

Abstract

A recurrence of bladder tumors following surgery for transitional cell carcinoma of the upper urinary tract is not rarely observed. A prospective randomized study was conducted to examine the significance of prophylactic intravesical instillation of mitomycin C (MMC) and cytosine arabinoside (Ara-C) to prevent recurrent bladder tumors after surgery for superficial transitional cell carcinoma of the upper urinary tract. The patients were randomized into an instillation group, who received postoperative intravesical instillation of MMC (20 mg) and Ara-C (200 mg) 28 times over a period of 2 years, and a non-instillation group. The non-recurrence rate was then compared between the groups. Of the 27 patients registered, 25 patients (13 with instillation and 12 without instillation) were able to be evaluated, with a median follow-up period of 45 months. The non-recurrence rate of bladder tumors in the instillation group was higher than that in the non-instillation group. Although the difference was not statistically significant, the P-value (P = 0.079) demonstrated a strong trend. When any possible bias was allowed for a multivariate analysis, the difference was almost significant (P = 0.0567). No patients withdrew from this study du...Continue Reading

References

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Citations

Sep 6, 2013·Japanese Journal of Clinical Oncology·Akihiro ItoUNKNOWN Tohoku Urological EBM Study Group
Jul 25, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Norihito SogaYoshiki Sugimura
Oct 17, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Teng-Fu HsiehChih-Rong Shyr
Oct 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Renzo ColomboMichele Pavone-Macaluso
Jan 13, 2018·Japanese Journal of Clinical Oncology·Idir OuzaidUNKNOWN Young Academic Urologists of the European Association of Urology Urothelial Carcinoma Group
Aug 24, 2006·Expert Review of Anticancer Therapy·Christian BolenzMaurice Stephan Michel
May 19, 2019·The Cochrane Database of Systematic Reviews·Eu Chang HwangMichael C Risk
Sep 17, 2020·Der Urologe. Ausg. A·A J GrossB Becker
Aug 13, 2021·BJU International·Yasuyoshi MiyataUNKNOWN Nagasaki University Urological Oncology Research Group

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