Prophylactic lactoferrin for preventing late-onset sepsis and necrotizing enterocolitis in preterm infants: A PRISMA-compliant systematic review and meta-analysis

Medicine
Yi HeJialin Yu

Abstract

Currently, prophylactic use of drugs to promote a healthy gut microbiota and immune system in preterm infants is hot debated, among which lactoferrin is a promising supplementation. However, the effect and safety of lactoferrin to prevent late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) in preterm infants remains controversial. Databases including Medline, Ovid-Embase, The Cochrane Library, CBM, CNKI, and VIP database of Chinese Journal were searched to collect randomized controlled trials (RCTs) about lactoferrin for preventing LOS and NEC in preterm infants. Languages of included RCTs were restricted to English and Chinese. Meta-analysis was conducted by Rev Man 5.3 software. The Mantel-Haenszel method with random-effects model was used to calculate pooled relative risks (RRs) and 95% confidence intervals (CIs). A total of 9 RCTs, involving 1834 patients, were included. Pooled analysis showed that prophylactic lactoferrin could significantly reduce the incidence all culture-proven LOS (41/629 [6.5%] vs 96/659 [15.3%]; RR 0.47; 95% CI 0.33-0.67; P < .01) and NEC (stage II or more) (9/448 [2.0%] vs 26/462 [5.6%]; RR 0.40; 95% CI 0.18-0.86; P < .01). Lactoferrin was also associated with a significantly decreased hospi...Continue Reading

References

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Citations

May 29, 2019·The Journal of Infectious Diseases·Kathryn R MichelsJennifer R Bermick
Oct 3, 2019·Cellular and Molecular Life Sciences : CMLS·Max Van BelkumJosef Neu
Apr 17, 2019·Digestive Diseases and Sciences·Kewei WangKarl G Sylvester
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Jul 23, 2020·The Journal of Perinatal & Neonatal Nursing·Jordan Mattern, Terri Marin
Sep 19, 2019·American Journal of Perinatology·Abdul Razak, Asif Hussain
Mar 23, 2021·Critical Reviews in Food Science and Nutrition·Yun-Shan WeiHong Wu
Mar 26, 2021·International Immunopharmacology·Michał ZimeckiMarian L Kruzel
Jul 21, 2021·Annual Review of Nutrition·Saurabh MehtaJulia L Finkelstein

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Software Mentioned

Rev Man
Embase
Cochrane Risk - of - Bias Tool

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