Prophylactic milrinone for the prevention of low cardiac output syndrome and mortality in children undergoing surgery for congenital heart disease

The Cochrane Database of Systematic Reviews
Barbara E U BurkhardtBrigitte Stiller


Children with congenital heart disease often undergo heart surgery at a young age. They are at risk for postoperative low cardiac output syndrome (LCOS) or death. Milrinone may be used to provide inotropic and vasodilatory support during the immediate postoperative period. This review examines the effectiveness of prophylactic postoperative use of milrinone to prevent LCOS or death in children having undergone surgery for congenital heart disease. Electronic and manual literature searches were performed to identify randomised controlled trials. We searched CENTRAL, MEDLINE, EMBASE and Web of Science in February 2014 and conducted a top-up search in September 2014 as well as clinical trial registries and reference lists of published studies. We did not apply any language restrictions. Only randomised controlled trials were selected for analysis. We considered studies with newborn infants, infants, toddlers, and children up to 12 years of age. Two review authors independently extracted data according to a pre-defined protocol. We obtained additional information from all study authors. Three of the five included studies compared milrinone versus levosimendan, one study compared milrinone with placebo, and one compared milrinone ve...Continue Reading


Nov 1, 1984·Archives internationales de physiologie et de biochimie·D el AllafJ Carlier
Jul 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·V RaoT E David
Feb 1, 1997·Journal of Cardiothoracic and Vascular Anesthesia·L A DoolanA M Tonkin
Apr 13, 2001·Journal of the American College of Cardiology·C A WarnesG D Webb
May 16, 2002·Current Opinion in Pediatrics·Shane M Tibby, Ian A Murdoch
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Apr 10, 2004·Journal of Cardiothoracic and Vascular Anesthesia·Vadim KhazinTiberiu Ezri
Apr 30, 2004·Statistics in Medicine·Michael J SweetingPaul C Lambert
Sep 7, 2004·Journal of Pharmacokinetics and Pharmacodynamics·James M BaileyGil Wernovsky
Sep 13, 2005·Biology of the Neonate·Dirk BasslerHaresh Kirpalani
Dec 14, 2005·Statistics in Medicine·Roger M HarbordJonathan A C Sterne
May 6, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Yunseok JeonJu Youn Choi
Jul 11, 2006·Current Opinion in Anaesthesiology·Christian F Stocker, Lara S Shekerdemian
Sep 27, 2006·European Heart Journal·Markku S NieminenUNKNOWN Heart Failure Association, European Society of Cardiology
Feb 3, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Ilhan OztekinSevim Canik
May 1, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Joris LemsonJohannes G van der Hoeven
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Sep 17, 2009·European Journal of Pediatrics·Daniel Dilber, Ivan Malcić
Dec 25, 2009·Circulation. Cardiovascular Quality and Outcomes·Sara K PasqualiSamir S Shah
Feb 9, 2010·Interactive Cardiovascular and Thoracic Surgery·Eva Maria Delmo WalterRoland Hetzer
Jul 27, 2010·Biostatistics·Gerta RückerMartin Schumacher
Aug 13, 2010·Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen·Guido Schwarzer, Gerta Rücker
Sep 11, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Mona MomeniThierry Detaille
Mar 30, 2011·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Desmond Bohn
Jun 21, 2011·Methodist DeBakey Cardiovascular Journal·Peter R Ermis, David L S Morales
Aug 20, 2011·Paediatric Anaesthesia·Winnie Vogt, Stephanie Läer
Oct 29, 2011·Archives of Disease in Childhood·Winnie Vogt, Stephanie Läer

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Sep 30, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Shannon N GriffithChristopher A Thomas
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