Prophylactic or therapeutic doses of heparins for COVID-19 infection? A retrospective study.

Aging Clinical and Experimental Research
Francesco BolzettaNicola Veronese

Abstract

Coronavirus disease 19 (COVID-19) is a global outbreak. COVID-19 patients seem to have relevant coagulative abnormalities, even if they are not typical of disseminated intravascular coagulopathy (DIC) of the kind seen in septicaemia. Therefore, anticoagulant therapy with heparins is increasing in interest for a clinical approach to these patients, particularly if older. Studies comparing if prophylactic doses are more effective than therapeutic ones are still missing. Data were collected in the Geriatric Section of the Dolo Hospital, ULSS 3 "Serenissima", Venice from 31st March to 01st May 2020. Heparins (calciparin, fondaparinux, enoxaparine) were divided into prophylactic or therapeutic doses. People previously treated with oral anticoagulants were removed. Vital status was assessed using administrative data. Cox's regression analysis, adjusted for potential confounders, was used for assessing the strength of the association between heparins and mortality. The data were reported as hazard ratio (HR) with 95% confidence intervals (CIs). 81 older people (mean age 84.1 years; females = 61.9%) were included. No significant differences in terms of demographic and clinical characteristics emerged between people treated with prophyl...Continue Reading

References

Apr 16, 2020·Journal of Thrombosis and Haemostasis : JTH·Deepa R J Arachchillage, Mike Laffan
Apr 28, 2020·Journal of Thrombosis and Haemostasis : JTH·Jecko ThachilToshiaki Iba
May 1, 2020·European Heart Journal. Cardiovascular Pharmacotherapy·Bassam AtallahWael AlMahmeed
May 1, 2020·Thrombosis Research·Corrado LodigianiUNKNOWN Humanitas COVID-19 Task Force
May 6, 2020·Journal of Thrombosis and Haemostasis : JTH·Saskia MiddeldorpNick van Es
May 15, 2020·The Lancet. Haematology·Marcel LeviJerrold H Levy
Jun 23, 2020·Journal of Cardiovascular Pharmacology·Elizabeth M GavioliEtty Vider
Jul 18, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Wolfgang Miesbach, Michael Makris

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Citations

Jul 31, 2021·Infectious Diseases and Therapy·Matteo BassettiUNKNOWN Italian Society of Anti-infective Therapy (SITA) and the Italian Society of Pulmonology (SIP)

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