PMID: 53548Nov 22, 1975Paper

Prophylactic oral antimicrobial agents in elective colonic surgery. A controlled trial

Lancet
J GoldringG Gillespie

Abstract

A controlled trial has been carried out in 50 patients undergoing elective colonic surgery to assess the efficacy of prophylactic oral metronidazole specifically directed against anaerobic colonic microflora in combination with kanamycin to reduce the aerobic flora. A control group received dietary and mechanical preparation alone. A significant reduction of both aerobic and anaerobic colonic microflora was achieved in the group receiving prophylactic antimicrobial agents, and this was reflected in a significant reduction in postoperative wound infections. 1 control patient died from Bacteroides septicaemia. No toxic or other side-effects from this prophylactic regimen occurred in this trial.

Citations

Mar 1, 1979·The British Journal of Surgery·S A TaylorJ Smith
May 1, 1982·World Journal of Surgery·M R Keighley
Mar 1, 1982·World Journal of Surgery·R E Condon
Jun 1, 1984·World Journal of Surgery·H L Young, M H Wheeler
Mar 1, 1993·World Journal of Surgery·W T Morris
Jan 1, 1989·Diseases of the Colon and Rectum·I T KhubchandaniR D Riether
May 1, 1983·Diseases of the Colon and Rectum·J PortnoyJ Mendelson
Nov 1, 1978·Diseases of the Colon and Rectum·V A DeGennaroM C Veidenheimer
Sep 1, 1980·Diseases of the Colon and Rectum·S MinerviniM R Keighley
Jul 1, 1977·Diseases of the Colon and Rectum·R DowningM R Keighley
Mar 1, 1980·Diseases of the Colon and Rectum·K C HanelE Reiss-Levy
Nov 1, 1981·Diseases of the Colon and Rectum·P B Christensen, O Kronborg
Sep 1, 1985·Irish Journal of Medical Science·N Buckley, J S Lavelle
Apr 1, 1984·Irish Journal of Medical Science·M K O'MalleyJ S Lavelle
Jun 1, 1994·Mutation Research·L DobiásR Srám
May 1, 1996·Immunology Today·Y H SongN K Maclaren
Mar 7, 2013·Surgical Infections·Dale W BratzlerSociety for Healthcare Epidemiology of America (SHEA)
Apr 15, 2004·Annals of Surgery·Robert L SmithEugene F Foley
Sep 1, 1984·Clinical and Experimental Pharmacology & Physiology·A V Kurpad, P S Shetty
Feb 1, 1979·The Australian and New Zealand Journal of Surgery·M Killingback
Apr 1, 1992·The Australian and New Zealand Journal of Surgery·J W LumleyS White
Mar 1, 1978·Antimicrobial Agents and Chemotherapy·F P TallyS L Gorbach
Jul 1, 1979·Antimicrobial Agents and Chemotherapy·M L Britz, R G Wilkinson
Dec 11, 1976·British Medical Journal·S J Eykyn, I Phillips
Aug 6, 1977·British Medical Journal·T T IrvinH L Duthie
Sep 25, 1982·British Medical Journal·N I WilsonC S McArdle
Jan 1, 1986·Gut·A V Kurpad, P S Shetty
Sep 1, 1976·Postgraduate Medical Journal·K E Hobbs
Jan 1, 1978·Scandinavian Journal of Infectious Diseases·E BäckM Wickman
Feb 1, 1985·The Australian and New Zealand Journal of Surgery·M T Pheils
Jan 24, 2018·World Journal of Gastrointestinal Surgery·Shamir O CawichVijay Naraynsingh
Jul 1, 1987·The British Journal of Surgery·A D Irving, D Scrimgeour
Feb 1, 1985·The British Journal of Surgery·M E FosterR C Williamson
May 13, 2014·The Cochrane Database of Systematic Reviews·Richard L NelsonMarija Barbateskovic
May 7, 2002·The Journal of Urology·Kenneth H FergusonAllen F Morey
Nov 1, 1978·The British Journal of Surgery·O Khan, H H Nixon
Nov 1, 1983·The British Journal of Surgery·N J MitchellD Pollock
May 1, 1977·The British Journal of Surgery·M R Keighley
Apr 1, 1982·The British Journal of Surgery·F D BeggsJ W Holmes
Aug 1, 1980·The British Journal of Surgery·A K HalsallR N Peel
Aug 1, 1978·The British Journal of Surgery·Y ArabiM R Keighley
Dec 25, 2008·Annals of Surgery·Jensen T PoonOswens S H Lo
Oct 29, 2015·International Journal of Colorectal Disease·Derek B HennesseyKenneth Mealy
Apr 1, 1979·Scottish Medical Journal·J A Gray
Apr 1, 1977·Scottish Medical Journal·A T Willis
Jan 1, 1982·Scandinavian Journal of Infectious Diseases·R HoelI Matheson
May 1, 1987·Drug Intelligence & Clinical Pharmacy·L Danziger, E Hassan
Jul 2, 1992·Journal of Wound Care·S F MishrikiD J W Law
Jan 25, 2013·Journal of the Korean Society of Coloproctology·In Ho SongKyu Joo Park
Jan 7, 1984·The Medical Journal of Australia·A R Askew
Feb 24, 1979·The Medical Journal of Australia·P S HuntA Sali

Related Concepts

Bacteroides
Clinical Trials
Taenia Coli
Colonic Diseases
Malignant Tumor of Colon
Alkalescens-Dispar Group
Feces
Kantrex
Bayer 5360
Preoperative Procedure

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.