Prophylactic photobiomodulation therapy using 660 nm diode laser for oral mucositis in paediatric patients under chemotherapy: 5-year experience from a Brazilian referral service

Lasers in Medical Science
Laiz Fernandes Mendes NunesTarcília Aparecida Silva

Abstract

The use of photobiomodulation therapy (PBMT) in the prevention of oral mucositis (OM) in paediatric care has increased. In this article, we report data of paediatric oncology/haematopoietic stem cell transplantation (HSCT) patients treated with PBMT to prevent chemotherapy-induced OM. A retrospective study was conducted at a Brazilian referral service. Prophylactic PBMT was used in children and adolescents (≤ 17 years) following the protocol: InGaAIP, 660 nm, 100 mW, 2 J, 3.33 W/cm2, and 20 s per point. Demographic data and OM severity scores were assessed. A regression model tested the association between OM with prophylactic PBMT and antineoplastic therapy. A total of 148 individuals who had undergone 358 chemotherapy cycles were analysed. A higher occurrence of OM was observed in HSCT and osteosarcoma (OS) patients. Except for HSCT, OM was associated with methotrexate (MTX) use in all disease groups. PBMT significantly reduced OM severity in acute lymphoblastic leukaemia (ALL) and OS patients. OM grade was 3.16 and 5.45 times higher among individuals with ALL and OS, who had not undergone prophylactic PBMT compared with those who had undergone prophylactic PBMT (p < 0.001). PBMT prevented chemotherapy-induced OM. Individuals...Continue Reading

References

Jul 1, 1997·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·L Kennedy, J Diamond
Feb 16, 2005·Cancer·Eva Steliarova-FoucherPeter Kaatsch
Apr 3, 2007·International Journal of Radiation Oncology, Biology, Physics·Linda S EltingAdam S Garden
Mar 4, 2008·Journal of Clinical Epidemiology·Andre Knottnerus, Peter Tugwell
Jul 31, 2009·International Journal of Cancer. Journal International Du Cancer·Beatriz de CamargoMaria S Pombo-de-Oliveira
Sep 29, 2009·Brazilian Dental Journal·Vivian Youssef KhouriJúlio César Voltarelli
Sep 17, 2011·International Journal of Paediatric Dentistry·Thais Morales-RojasAlejandra Alvarez
Nov 24, 2011·Photomedicine and Laser Surgery·Peter A Jenkins, James D Carroll
Dec 15, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Karis Kin Fong ChengJoel B Epstein
Oct 31, 2012·Cytokine·Pedro M G SoaresMarcellus H L P Souza
Feb 16, 2013·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Misty M MillerTracy M Hagemann
Oct 8, 2013·The American Journal of Pathology·Giulia OttavianiSerena Zacchigna
Jan 1, 2014·International Journal of Paediatric Dentistry·Maddalena ChermetzSerena Zacchigna
Mar 17, 2015·Current Opinion in Oncology·Alessandro Villa, Stephen T Sonis
Mar 31, 2015·American Journal of Human Biology : the Official Journal of the Human Biology Council·Ronald Rodrigues de MouraLucas André Cavalcanti Brandão
Jun 19, 2015·Pediatric Hematology and Oncology·Regina Maria Holanda de MendonçaSilvia Regina Brandalise
Jul 16, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A M ClementeM Monici
Jan 1, 2016·Journal of Biomedical Optics·Marina CurraManoela Domingues Martins
Apr 16, 2017·The Lancet Oncology·Eva Steliarova-FoucherUNKNOWN IICC-3 contributors
Nov 23, 2017·Photochemistry and Photobiology·Michael R Hamblin
Nov 28, 2017·Photodiagnosis and Photodynamic Therapy·Vânia Cavalcanti Ribeiro da SilvaGustavo Pina Godoy
Apr 26, 2018·Einstein·Marina CurraPaulo Sérgio da Silva Santos
Aug 1, 2018·European Journal of Paediatric Dentistry : Official Journal of European Academy of Paediatric Dentistry·J A Garrocho-RangelA Pozos-Guillén
Nov 14, 2018·Pediatric Blood & Cancer·Fatemeh MazhariMahboubeh Shabzendehdar
Jul 10, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Yehuda ZadikUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Jul 10, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Noam YaromUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society of Oral Oncology
Jul 10, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·J BowenUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Aug 3, 2019·The Lancet Oncology·UNKNOWN GBD 2017 Childhood Cancer Collaborators

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