PMID: 9658386Jul 11, 1998Paper

Prophylactic sodium valproate therapy in patients with drug-resistant migraine

Methods and Findings in Experimental and Clinical Pharmacology
K Ghose, B Niven

Abstract

We assessed the efficacy of sodium valproate as a prophylactic agent in migraine headache. A prospective randomized study was conducted in adult patients who previously derived no significant benefit from most conventional prophylactic therapy for migraine. Twenty-seven patients with a diagnosis of migraine with aura or migraine without aura from a headache clinic received low dose sodium valproate for 3 months. Response to therapy was defined as 50% or greater reduction in the frequency of headache. Plasma drug level monitoring helped to identify four noncompliers who were excluded from the study. Seventeen (71%) patients observed improvement within 4-6 weeks of medication and remained well for 12 weeks. They were further followed up for 12-24 months. Two patients for side effects and 1 for nondrug-related problems were withdrawn from follow-up study. Twelve patients (60%) maintained their response for 12 months or longer. Clinical improvement (percentage reduction in the frequency of migraine attacks) correlated inversely with the plasma drug levels at 13-24 months and daily dose of valproate, among the responders, suggestive of a possible therapeutic window. In other words, patients who do not respond to low dose valproate a...Continue Reading

Citations

Feb 21, 2004·Neuropharmacology·Eduardo D Martín, Miguel A Pozo
Jun 19, 2014·Expert Opinion on Pharmacotherapy·Lorenza ChiossiPaolo Martelletti
Dec 15, 2006·Pain Practice : the Official Journal of World Institute of Pain·Florian StrasserAllen W Burton
Dec 23, 2008·Arquivos de neuro-psiquiatria·Elcio Juliato PiovesanLineu César Werneck
Jun 26, 2013·The Cochrane Database of Systematic Reviews·Mattias LindeDouglas C McCrory
Dec 25, 2009·CNS Drugs·Michail Vikelis, Alan M Rapoport
May 28, 2016·The Cochrane Database of Systematic Reviews·Edward P Chronicle, Wim M Mulleners
Jul 9, 2003·CNS Drug Reviews·Cecilie U Johannessen, Svein I Johannessen
Jun 24, 2010·Acta Neurologica Scandinavica·R ShahienA Bowirrat

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