PMID: 11899651Mar 20, 2002Paper

Prophylactic surgery for women at high risk for breast cancer

Clinical Breast Cancer
D K Blanchard, L C Hartmann

Abstract

Women at high risk for the development of breast cancer have several options open to them including increased cancer surveillance, prophylactic mastectomy and/or oophorectomy, and chemoprevention. We consider high-risk women to be those with known BRCA mutations or a strong family history characterized by multiple relatives with breast cancer, early age at diagnosis, and in some families, ovarian cancer. We present existing data regarding prophylactic surgery for these women. Essentially, a woman at high risk for breast cancer may choose to undergo bilateral prophylactic mastectomy, with or without reconstruction. For patients who have a known breast cancer, contralateral mastectomy is also an option. Finally, for women in families with a strong incidence of ovarian cancer, prophylactic oophorectomy can be considered.

References

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Citations

Feb 3, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Claudio PonticelliGiuseppe Montagnino
Oct 28, 2006·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Suzanne M O'NeillWendy S Rubinstein
Jun 23, 2007·Journal of Evolutionary Biology·S A M VarelaR H Wagner
Aug 18, 2005·Annals of Plastic Surgery·Karl H Breuing, Stephen M Warren
Mar 10, 2011·Aesthetic Surgery Journal·G Patrick MaxwellAllen Gabriel
Aug 17, 2004·Molecular Endocrinology·Erik JansenBart C J M Fauser
Dec 8, 2009·Surgery·Kaye M Reid-Lombardo, Gloria M Petersen

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