PMID: 9549743Apr 29, 1998Paper

Prophylactic therapy with granisetron in the prevention of vomiting after paediatric surgery. A randomized, double-blind comparison with droperidol and metoclopramide

Paediatric Anaesthesia
Y Fujii, H Tanaka

Abstract

The antiemetic efficacy of droperidol, metoclopramide and granisetron was compared with placebo in the reduction of vomiting after paediatric surgery (the extremities; inguinal hernia; and phimosis) during general inhalational anaesthesia. One hundred children, ASA physical status I, 4-10 years of age, were enrolled in a prospectively, randomized, double-blind investigation and assigned to one of four treatment regimens: placebo (saline, n = 25), droperidol (50 micrograms.kg1, n = 25), metoclopramide (0.25 mg.kg-1, n = 25) or granisetron (40 micrograms.kg-1, n = 25). These drugs were administered intravenously (i.v.) after inhalation induction of anaesthesia. A complete response, defined as no emesis and no need for another rescue antiemetic during the first 24 h after anaesthesia, occurred in 60%, 76%, 68% and 88% of patients who had received placebo, droperidol, metoclopramide and granisetron, respectively (P < 0.05; overall Fisher's exact probability test). The incidence of adverse events postoperatively was not different among the treatment groups. In conclusion, granisetron 40 micrograms.kg-1 is a better antiemetic than droperidol and metoclopramide when compared to placebo for the prevention of postoperative emesis in chi...Continue Reading

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Citations

Mar 17, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H M MunroA R Tait
Jun 30, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·I HenziM R Tramèr
Nov 7, 2001·Paediatric Anaesthesia·A GloorA Gerber
Mar 21, 2002·Paediatric Anaesthesia·Yoshitaka Fujii, Hiritoshi Tanaka
Aug 12, 2006·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Christine M StorkLawrence H Brown
Mar 20, 1999·European Journal of Anaesthesiology·Y Fujii, H Tanaka
Oct 4, 2006·Current Opinion in Anaesthesiology·R Aantaa, T Manner
Jul 18, 2017·The Cochrane Database of Systematic Reviews·John Carlisle, Carl A Stevenson

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