PMID: 7025721Oct 1, 1981Paper

Prophylactic trimethoprim-sulfamethoxazole during consolidation chemotherapy for acute leukemia: a controlled trial

Annals of Internal Medicine
B WeiserD Armstrong

Abstract

We conducted a prospective, controlled, randomized trial of oral trimethoprim-sulfamethoxazole treatment in patients with acute leukemia receiving consolidation chemotherapy. We followed 14 treatment patients during 33 episodes and 15 control patients during 34 episodes of granulocytopenia (less than 1000 granulocytes/mm3). We found no significant difference in the incidence of febrile episodes (13 in treatment group versus 14 in control group), hospitalizations to treat fever or infection (10 versus 12), number of documented infections (eight versus 10), number of septicemias (one versus two), or mean duration of hospital stay to treat fever or infection (8.9 versus 9.2 days) in the two groups. There was little colonization with organisms resistant to trimethoprim-sulfamethoxazole, including Candida, in either group. Prophylactic trimethoprim-sulfamethoxazole did not significantly reduce the incidence of fever, hospitalization, or infection in granulocytopenic patients during consolidation chemotherapy.

Citations

Oct 1, 1983·European Journal of Cancer & Clinical Oncology·T J Walsh, S C Schimpff
May 26, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M D van de WeteringH N Caron
Dec 1, 1992·Epidemiology and Infection·E KurrleW Kern
Jan 7, 1982·The New England Journal of Medicine·G A Jacoby
Jan 31, 2008·Leukemia & Lymphoma·Sarah P Hammond, Lindsey R Baden
Jan 1, 1988·Current Medical Research and Opinion·B E De PauwC Verhagen
Jan 1, 1988·Cancer Investigation·M RubinP A Pizzo
May 1, 1984·Chest·K R Hande, R M Des Prez
Jun 26, 1987·The American Journal of Medicine·C Lee, A R Ronald
Sep 1, 1991·The Journal of Hospital Infection·R E Warren
Jun 1, 1982·The American Journal of Medicine·K A Foon, R P Gale
Sep 1, 1994·The American Journal of Medicine·P Y BochudP Francioli
Dec 20, 1999·The Journal of Antimicrobial Chemotherapy·K G Kerr
Jan 20, 2012·The Cochrane Database of Systematic Reviews·Anat Gafter-GviliLeonard Leibovici
Oct 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J C Hoefs
Jan 27, 2007·The Cochrane Database of Systematic Reviews·J E ClarksonO B Eden

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