Prophylactic Use of Troxerutin Can Delay the Development of Diabetic Cognitive Dysfunction and Improve the Expression of Nrf2 in the Hippocampus on STZ Diabetic Rats

Behavioural Neurology
Songyun ZhangJie Li

Abstract

With the change in lifestyle and the aging population, the incidence of cognitive dysfunction in diabetes mellitus is rising sharply. Oxidative stress is an important mechanism in the development of diabetic cognitive dysfunction. Nuclear factor E2-related factor 2 (Nrf2) is the core transcription factor of antioxidative stress. Early prevention and treatment of diabetic cognitive dysfunction can reduce the incidence of dementia and improve the quality of life of diabetic patients. This study was aimed at determining effect of troxerutin on the development of cognitive dysfunction and the expression level of Nrf2 in the hippocampus of streptozotocin (STZ) diabetic rats, when used in the early preventive stage. An STZ-induced diabetic rat model was established (n = 30), and the animals were randomly divided into 2 groups: diabetic control group (DC, n = 15) and diabetic troxerutin intervention group (DT, n = 15). Another 10 normoglycemic rats were put into a normal control group (NC, n = 10). While the DT group was injected with troxerutin (60 mg/kg), the DC group and the NC group were injected with physiological saline for 12 weeks daily. Learning and memory behaviors were tested using the Morris water maze test. The superoxide...Continue Reading

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Citations

Jan 19, 2019·The Journal of Clinical Endocrinology and Metabolism·Anna ShalimovaKrzysztof Narkiewicz
Jul 1, 2020·Endocrine Regulations·Afsaneh GhadiriRana Keyhanmanesh

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Methods Mentioned

BETA
MDA
dissection
PCR
electrophoresis

Software Mentioned

SPSS
EthoVision

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