PMID: 9449585Jan 1, 1997Paper

Prophylaxis and treatment of bladder dysfunction after Wertheim-Meigs operation: the positive effect of early postoperative detrusor stimulation using the cholinergic drug betanecholchloride

International Urogynecology Journal and Pelvic Floor Dysfunction
B KempW Heyl

Abstract

The efficacy of betanecholchloride in the postoperative treatment of bladder dysfunction is controversial. We therefore performed a comparative study on the effect of this therapy for the prophylaxis of detrusor hypotonia after Wertheim-Meigs operation. Forty patients with cervical cancer FIGO stage Ib/IIa were divided into two study groups. The control group (24 patients) only received betanecholchloride if the residual urine persisted above 50 ml after the 10th postoperative day. The study group (16 patients) received 50 mg betanecholchloride three times a day from the 3rd postoperative day onward. In this group postoperative catheter treatment, and consequently hospital stay, were significantly shorter (9.6 versus 13.3 days and 15.5 versus 18.6 days). The residual urinary volume normalized faster (8.0 versus 13.0 days) and the rate of cystitis was lower (18.8 versus 25%). According to our study, a prophylactic application of the parasympathomimetic drug betanecholchloride diminishes postoperative complications associated with bladder dysfunction after Wertheim-Meigs operation.

References

Apr 1, 1987·British Journal of Obstetrics and Gynaecology·D I FarquharsonS J Soong
Sep 1, 1983·British Journal of Obstetrics and Gynaecology·N KadarJ H Nelson
Oct 15, 1980·American Journal of Obstetrics and Gynecology·J P Forney
Apr 1, 1981·American Journal of Obstetrics and Gynecology·J A LowJ A Carmichael
Sep 1, 1957·American Journal of Obstetrics and Gynecology·A R FLEMING

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Citations

Nov 3, 2009·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Sriram Krishnamoorthy, Nitin S Kekre
Nov 13, 2003·European Psychiatry : the Journal of the Association of European Psychiatrists·Hubertus HimmerichMatthias J Müller
Oct 12, 2010·The Cochrane Database of Systematic Reviews·Brian S Buckley, Marie Carmela M Lapitan
Dec 28, 2017·Investigative and Clinical Urology·Dae Kyung Kim
Jan 20, 2007·BJU International·Maurits M BarendrechtMartin C Michel
Dec 6, 2017·Expert Review of Clinical Pharmacology·Seyedeh-Sanam Ladi-SeyedianAbdol-Mohammad Kajbafzadeh
Jan 26, 2021·The Cochrane Database of Systematic Reviews·Apiwat Aue-AungkulPisake Lumbiganon

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