PMID: 7426509Jul 1, 1980

Prophylaxis for Mendelson's syndrome before elective caesarean section. A comparison of cimetidine and magnesium trisilicate mixture regimens

British Journal of Obstetrics and Gynaecology
R P Husemeyer, H T Davenport


A clinical trial was conducted in which patients undergoing elective Caesarean section received eitherrr oral cimetidine 400 mg or magnesium trisilicate mixture BPC 20 ml before anaesthesia. The pH values of gastric fluid were significantly higher and the incidence of pH less than 2.5 was significantly lower in patients who received magnesium trisilicate mixture BPC. No adverse effects were observed in newborn infants whose mothers had received cimetidine and there was no significant difference in pH values of gastric fluid from the newborn in the two groups. The findings suggest that as a means of prophylaxis for Mendelson's syndrome in patients undergoing elective Caesarean section, magnesium trisilicate mixture BPC 20 ml is more effective than a single oral dose of cimetidine 400 mg, administered in the manner described.


Oct 1, 1978·Anaesthesia·R P HusemeyerT Rajasekaran
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Mar 15, 2011·International Journal of Obstetric Anesthesia·Shantini ParanjothyJane Thomas
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Sep 14, 2012·The Cochrane Database of Systematic Reviews·James D GriffithsJane Thomas
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May 1, 1984·Drug Intelligence & Clinical Pharmacy·S F Kowalsky

Related Concepts

General Anesthesia
Paracervical Block
Postcesarean Section
Gastric Acidity Determination
Aspiration Pneumonia

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