Apr 22, 2009

Prophylaxis of heterotopic ossification - an updated review

Journal of Orthopaedic Surgery and Research
Evan O Baird, Qian K Kang

Abstract

Heterotopic ossification (HO) is defined as the process by which trabecular bone forms outside of the skeletal structure, occupying space in soft tissue where it does not normally exist. The current popular prophylactic treatment modalities include non-steroidal anti-inflammatory drugs (NSAIDs) and radiation therapy, although the literature remains inconclusive as to which is superior. Additionally, both treatments can lead to adverse effects to the patient. Recently there have been several studies attempting to identify new aspects of the etiology of heterotopic bone formation and introduce new prophylactic modalities with increased efficacy and fewer side effects. For this review, we selectively retrieved articles from Medline published from 1958-2008 on the prophylaxis of HO with the aim of assisting readers in quickly grasping the current status of research and clinical aspects of HO prophylaxis.

  • References51
  • Citations56

References

  • References51
  • Citations56

Citations

Mentioned in this Paper

NOG gene
Ischemia
Ibuprofen
Diagnostic Radiology Modality
Trabecular Substance of Bone
Allopurinol
Degenerative Polyarthritis
Ligaments
Bone morphogenetic protein 4
Hip Region Structure

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

International Journal of Radiation Oncology, Biology, Physics
Tracy A BalboniHarvey J Mamon
Journal of Rehabilitation Medicine
Luc Vanden Bossche, Guy Vanderstraeten
Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Francisco José Andreu MartínezVicente Tormo Ferrero
© 2020 Meta ULC. All rights reserved