Prophylaxis of migraine in children and adolescents

Paediatric Drugs
Joanne Kacperski

Abstract

While it has been established that headaches in the pediatric age group are relatively common, the characterization of headache disorders and their treatment in this group has historically been limited. Due to the paucity of controlled studies on prophylaxis of the primary headache disorders in children, the diagnosis of migraine often rests on criteria similar to those used in adults. Data from adult studies are often extrapolated and applied to the pediatric patient. Although it appears that many prophylactic agents are safe, well tolerated and efficacious in children, currently only topiramate is FDA-approved for use in patients 12 years and over. As a result, despite often experiencing significant disability, many children who present to their physician with migraines do not receive preventive therapy. One-third of adolescents meet the criteria for warranting prophylactic therapy, yet few are offered a preventative medication. Moreover, controlled clinical trials investigating the use of both abortive and prophylactic medications in children have suffered from high placebo response rates. A diverse group of medications are used to prevent migraine attacks, including antidepressants, antiepileptics, antihistamines and antihy...Continue Reading

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Citations

Mar 29, 2016·Seminars in Pediatric Neurology·Joanne KacperskiHeidi K Blume
Dec 24, 2015·Current Pain and Headache Reports·János TajtiLászló Vécsei
Sep 17, 2016·The Journal of Pediatrics·David C Sheridan, Garth D Meckler
Nov 23, 2016·Current Pain and Headache Reports·Thyra LanghagenKlaus Jahn
Aug 16, 2017·Holistic Nursing Practice·Suzy Mascaro Walter
Jun 4, 2019·Cephalalgia : an International Journal of Headache·Hadi MontazerlotfelahiMahmoud Reza Ashrafi
Apr 18, 2017·Pediatric Annals·Heidi K Blume
Sep 26, 2019·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Shengyuan YuYu Li
Dec 25, 2017·Paediatric Drugs·Jonathan RabnerAlyssa LeBel

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