PMID: 6405764Jun 1, 1983Paper

Prophylaxis of primary ventricular fibrillation with tocainide in acute myocardial infarction

British Heart Journal
R W CampbellE Taylor

Abstract

Within six hours of suspected acute myocardial infarction, 791 patients entered a randomised double blind study of combined intravenous and oral tocainide for the prophylaxis of primary ventricular fibrillation. Acute myocardial infarction was confirmed in 559 patients, of whom 278 had received tocainide. The study was terminated on the basis of a sequential statistical analysis which showed that in these patients tocainide was unlikely to reduce the incidence of primary ventricular fibrillation by as much as 50%, primary ventricular fibrillation having occurred in 4% of the tocainide and 2% of the placebo patients. Significantly fewer tocainide treated patients were withdrawn for other serious ventricular arrhythmias. Mortality (1% in the tocainide group and 2% in the placebo group) was low with no statistically significant differences between the active and placebo groups. Unwanted effects of treatment were infrequent and rarely troublesome both in patients with and without acute myocardial infarction. These results suggest that in the dosage used in this study tocainide does not exert an antifibrillatory action in the early phase of acute myocardial infarction.

References

Jan 1, 1979·Journal of Cardiovascular Pharmacology·R W CampbellD G Julian
Apr 1, 1978·Circulation·J L AndersonD C Harrison
Apr 1, 1978·The American Journal of Cardiology·E N MooreR A Moller
May 1, 1978·Annals of Internal Medicine·L J KagenR Roberts
May 6, 1974·The American Journal of Cardiology·D T JonesR W Gunton
Dec 4, 1969·The New England Journal of Medicine·J Koch-WeserR W DeSanctis
Dec 1, 1980·American Heart Journal·M D YoungH G Vassallo

❮ Previous
Next ❯

Citations

Jan 1, 1989·Journal of Psychosomatic Research·D H SykesK S Salathia
Jan 1, 1985·Molecular Aspects of Medicine·J H BottingM J Walker
Sep 28, 2007·Pacing and Clinical Electrophysiology : PACE·Haitham HreybeSamir Saba
Dec 21, 1984·The American Journal of Cardiology·R W Campbell
Jul 1, 1985·Drug Intelligence & Clinical Pharmacy·G R Hasegawa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.