Jul 1, 1989

Prophylaxis of recurrence of superficial bladder tumor by intravesical chemotherapy

Hinyokika kiyo. Acta urologica Japonica
R IkedaT Kudo


During the past 10 years, we have experienced 110 bladder tumor cases. Among them, 70 patients were diagnosed superficial bladder tumor. Of these 70 cases, 30 were treated with intravesical adriamycin (ADR) and peplomycin (PEP), 13 with ADR only and one case with PEP and remaining 26 with TUR and hydrostatic pressure technique. We studied the efficacy of combination intravesical chemotherapy with ADR and PEP and other treatments in the prevention of recurrence in the superficial bladder tumor cases. The recurrence rate during 3 years of each group, was 25% in the group treated with ADR and PEP, 35% with ADR and 55% in remaining group. 3 years recurrence rate in the group treated with ADR and PEP was significantly low than that in the group tread with TUR and hydrostatic pressure technique alone (Wilcoxon test). Side effects was pollakisuria, pain after micturition and others. Anaphylactic shock appeared in one case. From these results we concluded that intravesical chemotherapy with combined agents is more effective than that with a single one or no treatment after TUR.

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Mentioned in this Paper

Bladder Neoplasm
Neoplasm Recurrence, Local
Peplomycin Sulfate
Recurrent Malignant Neoplasm
Intravesical Injection
Antineoplastic Chemotherapy Protocols
Wilcoxon Signed Rank Test

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Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.