Propionate supplementation promotes the expansion of peripheral regulatory T-Cells in patients with end-stage renal disease.

Journal of Nephrology
Fabian MeyerNina Babel

Abstract

Patients with end-stage renal disease (ESRD) suffer from a progressively increasing low-grade systemic inflammation, which is associated with higher morbidity and mortality. Regulatory T cells (Tregs) play an important role in regulation of the inflammatory process. Previously, it has been demonstrated that short-chain fatty acids reduce inflammation in the central nervous system in a murine model of multiple sclerosis through an increase in tissue infiltrating Tregs. Here, we evaluated the effect of the short-chain fatty acid propionate on the chronic inflammatory state and T-cell composition in ESRD patients. Analyzing ESRD patients and healthy blood donors before, during, and 60 days after the propionate supplementation by multiparametric flow cytometry we observed a gradual and significant expansion in the frequencies of CD25highCD127- Tregs in both groups. Phenotypic characterization suggests that polarization of naïve T cells towards Tregs is responsible for the observed expansion. In line with this, we observed a significant reduction of inflammatory marker CRP under propionate supplementation. Of interest, the observed anti-inflammatory surroundings did not affect the protective pathogen-specific immunity as demonstrate...Continue Reading

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Citations

Apr 9, 2021·Nature Reviews. Nephrology·Paulo José BassoNiels Olsen Saraiva Câmara
May 13, 2021·Cell Reports·Derek J PlattJonathan J Miner
Aug 17, 2021·Frontiers in Immunology·Derek TobinPhilip C Calder

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Methods Mentioned

BETA
flow cytometry

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