Propionibacterium acnes Enhances the Immunogenicity of HIVBr18 Human Immunodeficiency Virus-1 Vaccine

Frontiers in Immunology
Daniela TeixeiraIeda Maria Longo-Maugéri

Abstract

Immunization of BALB/c mice with HIVBr18, a DNA vaccine containing 18 CD4+ T cell epitopes from human immunodeficiency virus (HIV), induced specific CD4+ and CD8+ T cell responses in a broad, polyfunctional and persistent manner. With the aim of increasing the immunogenicity of this vaccine, the effect of Propionibacterium acnes as an adjuvant was evaluated. The adjuvant effects of this bacterium have been extensively demonstrated in both experimental and clinical settings. Herein, administration of two doses of HIVBr18, in the presence of P. acnes, increased the proliferation of HIV-1-specific CD4+ and CD8+ T lymphocytes, the polyfunctional profile of CD4+ T cells, the production of IFN-γ, and the number of recognized vaccine-encoded peptides. One of the bacterial components responsible for most of the adjuvant effects observed was a soluble polysaccharide extracted from the P. acnes cell wall. Furthermore, within 10 weeks after immunization, the proliferation of specific T cells and production of IFN-γ were maintained when the whole bacterium was administered, demonstrating a greater effect on the longevity of the immune response by P. acnes. Even with fewer immunization doses, P. acnes was found to be a potent adjuvant capab...Continue Reading

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Citations

Mar 21, 2020·Frontiers in Immunology·Danielle A M da SilvaClara L Barbiéri
May 21, 2019·Frontiers in Immunology·Juliana de Souza ApostólicoDaniela Santoro Rosa
May 31, 2020·Journal of Medical Virology·Beniamino PalmieriClaudio Cermelli
Mar 23, 2021·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Beniamino Palmieri, Maria Vadalà

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Methods Mentioned

BETA
transgenic
transfection
amidation
flow cytometry

Software Mentioned

GraphPad Prism
TEPITOPE
Tree Star
FlowJo

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