Propionyl L-carnitine improvement of hypertrophied rat heart function is associated with an increase in cardiac efficiency

European Journal of Pharmacology
B O SchönekessG D Lopaschuk

Abstract

Although propionyl L-carnitine improves contractile function of hypertrophied rat hearts, the mechanism(s) by which it does this are not known. One postulated mechanism is that propionyl L-carnitine reverses the alterations in energy metabolism that occur secondary to the carnitine deficiency seen in hypertrophied myocardium. This study determined the effects of chronic propionyl L-carnitine administration on myocardial carnitine content and energy metabolism in hypertrophic hearts from male Wistar Kyoto rats. Pressure-overload hypertrophy was produced by constriction of the abdominal aorta in juvenile rats. Propionyl L-carnitine was administered to the rats via the drinking water for an 8 week period (60 mg.kg(-1).day-1). Myocardial function and metabolic analysis was determined in isolated working hearts obtained from aortic-banded and sham-operated (control) animals at the end of the 8 week study period. Carnitine content was significantly decreased in hypertrophied hearts compared to control hearts, but was normalized by propionyl L-carnitine treatment. Propionyl L-carnitine treatment also prevented the decrease in cardiac work that occurred in hypertrophied hearts compared to control hearts. The primary change in energy su...Continue Reading

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Citations

Aug 2, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·H S LeongM F Allard
Jan 5, 2014·Canadian Journal of Physiology and Pharmacology·Athina A StrilakouCharis A Liapi
Aug 12, 2014·Biochemical Society Transactions·Osama Abo Alrob, Gary D Lopaschuk
Mar 20, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Nozomu FujiiHiroshi Inoue
Jul 15, 1997·Circulation·M F AllardG D Lopaschuk
Sep 22, 2011·Expert Review of Cardiovascular Therapy·Victor Marinescu, Peter A McCullough
Oct 31, 2020·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Chiara TognolaCristina Giannattasio
Oct 23, 1997·Journal of Cardiac Failure·R Ferrari, F De Giuli

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