PMID: 8602668Feb 1, 1996Paper

Propofol alters left ventricular afterload as evaluated by aortic input impedance in dogs

Anesthesiology
D LoweD C Warltier

Abstract

Systemic vascular resistance incompletely describes left ventricular afterload because of the phasic nature of arterial pressure and blood flow. Aortic input impedance is an experimental description of left ventricular afterload that incorporates the frequency- dependent characteristics and viscoelastic properties of the arterial system. The effects of propofol on aortic input impedance were examined using three variables derived from the three-element Windkessel model: characteristic aortic impedance, total arterial compliance, and total arterial resistance. Eight dogs were chronically instrumented for measurement of aortic pressure, left ventricular pressure, +dP/dt, subendocardial segment length, and aortic blood flow. Systemic hemodynamics and aortic blood pressure and flow waveforms were recorded in the conscious state and after a bolus of 5 mg x kg(-1) propofol and infusion for 15 min at 25, 50 and 100 mg x kg(-1) x h(-1). Aortic input impedance spectra were generated using power spectral analysis of aortic pressure and flow waveforms corrected for the phase responses of the pressure and flow transducers. Characteristic aortic impedance, total arterial resistance, and total arterial compliance were calculated from the aor...Continue Reading

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Citations

May 6, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Daisuke TakizawaFumio Goto
Apr 1, 1997·Anesthesia and Analgesia·D A HettrickD C Warltier
May 29, 2002·Anesthesia and Analgesia·Franz KehlPaul S Pagel
Feb 3, 1998·Anesthesiology·P S PagelD C Warltier
Sep 14, 2007·Veterinary Anaesthesia and Analgesia·Christine BaumgartnerWolf Erhardt
Jul 16, 2010·Acta Anaesthesiologica Scandinavica·Y L J M DeryckS Brimioulle
Mar 13, 2012·Veterinary Anaesthesia and Analgesia·Martin A SuarezMarthinus Hartman
May 17, 2006·Seminars in Cardiothoracic and Vascular Anesthesia·J G Bovill
Feb 7, 2018·Artificial Organs·Sarah Nicole Fernández LafeverJesus Lopez-Herce
Jul 13, 2016·Circulation·Robert L PageUNKNOWN American Heart Association Clinical Pharmacology and Heart Failure and Transplantation Committees of the Council on Clinical
Nov 4, 2021·Seminars in Cardiothoracic and Vascular Anesthesia·Roby SebastianLuis Zabala

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