Propofol and fentanyl compared with midazolam and fentanyl during third molar surgery

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
L P ParworthT Bennett

Abstract

The purpose of this study was to measure the safety and efficacy of propofol combined with fentanyl as sedative agents during third molar outpatient surgery. A double-blind, prospective, randomized clinical trial involving 57 patients undergoing removal of third molars under intravenous sedation between November 1994 and December 1995 was performed. Patients randomly received either propofol and fentanyl (P + F, th = 24) or midazolam and fentanyl (M + F, M = 33). Patient demographics, Corah anxiety scores, and physiologic parameters were determined preoperatively. All medications were titrated to the same clinical end point for sedation. Intraoperative physiologic parameters, cooperation, alertness, and pain scores were assessed. Postoperative recovery and degree of amnesia also were determined. There were no significant differences in either patient demographics or surgical characteristics between groups. The P + F group was significantly less cooperative than the M + F group. Pain during injection of propofol was a significant adverse side effect. Both groups experienced a small percentage of apneic episodes, but mechanical ventilation was never required. There were no differences in recovery between groups as measured by the...Continue Reading

Associated Clinical Trials

References

Jan 1, 1987·Anaesthesia·N Mackenzie, I S Grant
Feb 1, 1995·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·L M Candelaria, R K Smith

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Citations

May 4, 2004·The British Journal of Oral & Maxillofacial Surgery·Zuhal Küçükyavuz, Mine Cambazoğlu
Feb 7, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Dae-Seung RyuIn-Hwan Oh
Jul 18, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Kyle S EttingerKevin Arce
Mar 21, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Figen Cizmeci SenelGeorge Obeid
Aug 19, 2006·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Joseph E Cillo, Richard Finn
Mar 21, 2006·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Angelle M Casagrande
Mar 25, 2005·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Emin EsenZ Nazan Alparslan
Aug 19, 2006·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Yakup UstünM Emre Benlidayi
Apr 19, 2019·Journal of Maxillofacial and Oral Surgery·Vikas SharmaAkanksha Zutshi
Feb 28, 2001·Australian Dental Journal·J P RogersA E Gale
Aug 1, 2015·Journal of Maxillofacial and Oral Surgery·P Hari KeerthyMueedul Islam
Dec 20, 2007·Pediatric Emergency Care·Ghazala Q SharieffJim R Harley

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