PMID: 9661091Jul 14, 1998Paper

Propofol and methohexital as anesthetic agents for electroconvulsive therapy (ECT): a comparison of seizure-quality measures and vital signs

The Journal of ECT
C GeretseggerA F Unterrainer

Abstract

In a randomized crossover study, the influence of the anesthetics methohexital and propofol on EEG seizure parameters, seizure-quality measures, vital signs, and oxygen saturation (SpO2) and end-tidal carbon dioxide tension (ETCO2) was investigated; 146 treatments of 31 patients were analyzed. Significant differences were observed between agents for mean postictal pulse and blood pressure values. With methohexital, there was a clear postictal increase of mean blood pressure from 126/78 mm Hg to 161/102 mm Hg, whereas there was no increase with propofol (p = 0.00), and with methohexital, a postictal increase of the mean pulse rate from 81 to 90 beats/min and a slight decrease with propofol (79 to 78 beats/min). There were no differences in the SpO2 and ETCO2. The mean seizure duration for unilateral treatments was significantly longer with methohexital (52.7 s) compared with propofol (34.1 s; p = 0.000), but there was no difference for the seizure-quality measures: postictal suppression index (propofol 79.7%, methohexital 77.4%) and mean integrated amplitude (30.2/31.8) were the same for both anesthetic agents. The results show that differences in seizure duration are unrelated to seizure-quality measures.

Citations

Feb 13, 2007·Der Anaesthesist·U Grundmann, M Oest
Jan 5, 2000·Drug and Alcohol Dependence·E M WeertsR R Griffiths
Apr 11, 2001·Journal of Neurosurgical Anesthesiology·B WalderM R Tramèr
Oct 24, 2002·The Journal of ECT·Catherine DattoStanley N Caroff
Apr 2, 2002·The Journal of ECT·Cornelis StadtlandNikolaus Michael
Dec 6, 2003·The Journal of ECT·Chadi A CalargeRobert P From
Dec 14, 2004·The Journal of ECT·Gábor GazdagZsolt Iványi
Dec 5, 2006·The Journal of ECT·Jennifer C SwaimJeffrey L Moore
Jul 17, 2008·The Journal of ECT·W Michael Hooten, Keith G Rasmussen
Jun 16, 2016·Frontiers in Psychology·Carmen Selva-SevillaMaria Teresa Tolosa-Perez
Apr 12, 2014·The Cochrane Database of Systematic Reviews·Peng LihuaPatrick Ziemann-Gimmel
Apr 23, 2005·The Cochrane Database of Systematic Reviews·P Tharyan, C E Adams

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