Propofol anesthesia increases dopamine and serotonin activities at the somatosensory cortex in rats: a microdialysis study

Anesthesia and Analgesia
M H ShyrP P Tan

Abstract

We sought to estimate the activities of dopamine and serotonin in animals receiving propofol anesthesia. The in vivo microdialysis technique was used in Sprague-Dawley rats (n = 6) to measure the major metabolites of dopamine and serotonin, i.e. 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (4-hydroxy-3-methyphenylacetic acid; HVA) and 5-hydroxy indole acetic acid (5-HIAA) in the somatosensory cortex. We also measured the levels of propofol in the brain and blood by microdialysis sampling in another group of rats (n = 6). During the experiment, the rat was infused intravenously (IV) with propofol at a rate of 10 mg x kg(-1) x h(-1) for 60 min and 60 mg x kg(-1) x h(-1) for 40 min. We found that IV infusion of propofol at a rate of 60 mg x kg(-1) x h(-1) significantly increased DOPAC, HVA, and 5-HIAA. We also determined that these changes correlated well with propofol levels in the brain and blood. We concluded that anesthetic doses of propofol increased the functional activities of dopamine and serotonin in the cortex. These increases correlate well with propofol levels in the cortex and blood.

References

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Citations

Mar 22, 2005·Psychopharmacology·C A StewardY B Shah
Feb 6, 2008·Journal of Neural Transmission·R AnckarsäterH Anckarsäter
Feb 3, 1998·Journal of Pharmaceutical and Biomedical Analysis·Y S WuF C Cheng
Jun 6, 2003·The Veterinary Journal·L BergamascoA Jaggy
Jul 12, 2008·International Anesthesiology Clinics·Christa J Van DortRalph Lydic
Mar 26, 2004·Anesthesia and Analgesia·Tetsuro ShirasakaMayumi Takasaki
Dec 5, 2002·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Henry G DunnGiovana V de Amorim
Sep 3, 2011·Journal of Neurochemistry·Christian P MüllerMaria A De Souza Silva
Jan 5, 2002·Journal of Neurosurgical Anesthesiology·John X Wilson, Adrian W Gelb

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