Propofol Anesthesia Increases Long-range Frontoparietal Corticocortical Interaction in the Oculomotor Circuit in Macaque Monkeys

Anesthesiology
Li MaAndrew E Hudson

Abstract

A decrease in frontoparietal functional connectivity has been demonstrated with multiple anesthetic agents, and this decrease has been proposed as a final common functional pathway to produce anesthesia.Two alternative measures of long-range cortical interaction are coherence and phase-amplitude coupling. Although phase-amplitude coupling within frontal cortex changes with propofol administration, the effects of propofol on phase-amplitude coupling between different cortical areas have not previously been reported. Using a previously published monkey electrocorticography data set, it was found that propofol induced coherent slow oscillations in visual and oculomotor networks made up of cortical areas with strong anatomic projections.Frontal eye field within-area phase-amplitude coupling increased.Contrary to expectations from previous functional connectivity studies, interareal phase-amplitude coupling also increased with propofol. Frontoparietal functional connectivity decreases with multiple anesthetics using electrophysiology and functional imaging. This decrease has been proposed as a final common functional pathway to produce anesthesia. Two alternative measures of long-range cortical interaction are coherence and phase-am...Continue Reading

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Citations

Feb 27, 2019·Anesthesiology·George A Mashour
Mar 15, 2019·Anesthesiology·George A Mashour
Mar 7, 2020·Neuron·George A MashourStanislas Dehaene
Jun 26, 2021·Royal Society Open Science·Thomas F VarleyAlice Patania
Jan 3, 2022·Cerebral Cortex·Camille GiacomettiCéline Amiez

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