Propofol-based anaesthesia versus sevoflurane-based anaesthesia for living donor kidney transplantation: results of the VAPOR-1 randomized controlled trial

British Journal of Anaesthesia
G J Nieuwenhuijs-MoekeM M R F Struys

Abstract

Kidney transplantation is associated with harmful processes affecting the viability of the graft. One of these processes is associated with the phenomenon of ischaemia-reperfusion injury. Anaesthetic conditioning is a widely described strategy to attenuate ischaemia-reperfusion injury. We therefore conducted the Volatile Anaesthetic Protection of Renal Transplants-1 trial, a pilot project evaluating the influence of two anaesthetic regimens, propofol- vs sevoflurane-based anaesthesia, on biochemical and clinical outcomes in living donor kidney transplantation. Sixty couples were randomly assigned to the following three groups: PROP (donor and recipient propofol), SEVO (donor and recipient sevoflurane), and PROSE (donor propofol and recipient sevoflurane). The primary outcome was renal injury reflected by urinary biomarkers. The follow-up period was 2 yr. Three couples were excluded, leaving 57 couples for analysis. Concentrations of kidney injury molecule-1 (KIM-1), N -acetyl-β- d -glucosaminidase (NAG), and heart-type fatty acid binding protein (H-FABP) in the first urine upon reperfusion showed no differences. On day 2, KIM-1 concentrations were higher in SEVO [952.8 (interquartile range 311.8-1893.0) pg mmol -1 ] compared wi...Continue Reading

Associated Clinical Trials

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Citations

Nov 16, 2019·Minerva urologica e nefrologica = The Italian journal of urology and nephrology·Raquel EchavarríaZesergio Melo
Sep 27, 2019·Journal of Clinical Medicine·Ho-Jin LeeWon Ho Kim
Apr 21, 2019·Drugs·Matthew Hulse, Mitchell H Rosner
Aug 20, 2020·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Rakesh V SondekoppamTimur J-P Özelsel
Jun 14, 2019·Dose-response : a Publication of International Hormesis Society·Hoon JungDong Gun Lim
Apr 4, 2021·Journal of Clinical Medicine·Mariana Gaya da CostaMichel M R F Struys
Apr 4, 2021·International Journal of Molecular Sciences·Gertrude J Nieuwenhuijs-MoekeHenri G D Leuvenink
May 17, 2017·British Journal of Anaesthesia·B Beck-SchimmerM Schläpfer

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