Propofol-Based Palliative Sedation to Treat Antipsychotic-Resistant Agitated Delirium

Journal of Pain & Palliative Care Pharmacotherapy
Alfredo Covarrubias-Gómez, Maria López Collada-Estrada

Abstract

Delirium is a common problem in terminally ill patients that is associated with significant distress and, hence, considered a palliative care emergency. The three subtypes of delirium are hyperactive, hypoactive, and mixed, depending on the level of psychomotor activity and arousal disturbance. When agitated delirium becomes refractory in the setting of imminent dying, the agitation may be so severe that palliative sedation (PS) is required. Palliative sedation involves the administration of sedative medications with the purpose of reducing level of consciousness for patients with refractory suffering in the setting of a terminal illness. Propofol is a sedative that has a short duration of action and a very rapid onset. These characteristics make it relatively easy to titrate. Reported doses range from 50 to 70 mg per hour. The authors present a case of antipsychotic-resistant agitated delirium treated with a propofol intravenous infusion.

References

Aug 1, 1983·The American Journal of Psychiatry·M J MassieE Glass
Nov 1, 1995·Journal of Pain and Symptom Management·J Moyle
Dec 17, 1997·Annals of Emergency Medicine·T R Coomes, S W Smith
Mar 29, 2000·Archives of Internal Medicine·P G LawlorE D Bruera
Jul 13, 2000·Critical Care Medicine·C McCowan, P Marik
Mar 13, 2002·Journal of Pain and Symptom Management·Christine ChengJose Pereira
Sep 1, 2005·Journal of Palliative Medicine·Tatsuya MoritaYosuke Uchitomi
Dec 27, 2005·Journal of Pain and Symptom Management·Staffan LundströmCarl Johan Fürst
Apr 25, 2006·Journal of Palliative Medicine·Egidio Del FabbroEduardo Bruera
Feb 2, 2008·Japanese Journal of Clinical Oncology·Chun-Kai FangYuen-Liang Lai
Jul 8, 2008·CNS Drugs·Azizah AttardDavid Taylor
Oct 16, 2009·Journal of Palliative Medicine·Kerry McWilliamsEsther T Waterhouse
Aug 4, 2010·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Marsha L Ellett
Sep 8, 2010·Journal of Pain and Symptom Management·Staffan LundströmAndrew Wilcock
Jan 1, 2010·Industrial Psychiatry Journal·Rajiv MahajanRanju Bala
Jun 12, 2012·Journal of Pain and Symptom Management·Susan B LeGrand
Jun 19, 2014·Pediatric Blood & Cancer·Daniel CombsLisa M Kopp
Sep 12, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N I Cherny, UNKNOWN ESMO Guidelines Working Group
Nov 13, 2015·Critical Care : the Official Journal of the Critical Care Forum·Adéla KrajčováFrantišek Duška

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