Propofol-based sedation does not negatively influence oxygenator running time compared to midazolam in patients with extracorporeal membrane oxygenation

The International Journal of Artificial Organs
Wolfgang LammThomas Staudinger

Abstract

Patients on extracorporeal membrane oxygenation are frequently in need for sedation. Use of propofol has been associated with impaired oxygenator function due to adsorption to the membrane as well as lipid load. The aim of our retrospective analysis was to compare two different sedation regimens containing either propofol or midazolam with respect to oxygenator running time. Midazolam was used in 73 patients whereas propofol was used in 49 patients, respectively. In the propofol group, veno-arterial-extracorporeal membrane oxygenation was used predominantly (84%), while veno-venous-extracorporeal membrane oxygenation was used more often in the midazolam group (64%). Oxygenator running time until first exchange was 7 days in both groups ( p = 0.759). No statistically significant differences could be observed between the subgroup of patients receiving lipid-free (n = 24) and lipid-containing (n = 31) parenteral nutrition, respectively. Laboratory parameters like triglycerides, free hemoglobin, fibrinogen, platelets, and activated partial thromboplastin time were not significantly different between both sedation regimens ( p = 0.462, p = 0.489, p = 0.960, p = 0.134, and p = 0.843) and were not associated with oxygenator running ti...Continue Reading

References

Jan 1, 1992·European Journal of Clinical Pharmacology·E Jacqz-AigrainF Beaufils
Jul 22, 1997·Biochemistry·M M Lopez, D Kosk-Kosicka
Mar 21, 2002·Critical Care Medicine·Judith JacobiUNKNOWN Task Force of the American College of Critical Care Medicine (ACCM) of the Society of Critical Care Medicine (SCCM), America
Dec 3, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Robert H Bartlett
Jul 4, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Luis Daniel Umezawa MakikadoJuan Carlos Montejo González
Apr 12, 2014·American Journal of Respiratory and Critical Care Medicine·Nick W LonardoRichard G Barton
Jan 31, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Hwee Min D LeeDavid M Wood
Dec 25, 2015·Anaesthesia Critical Care & Pain Medicine·Jean-Michel ConstantinBruno Perreira
Nov 11, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Benjamin HohlfelderJeremy R Degrado
Nov 11, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kai VerkoyenJustyna Swol
Dec 17, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Ravi R ThiagarajanUNKNOWN ELSO member centers
Oct 19, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Julian deBackerSangeeta Mehta
May 8, 2018·Journal of Thoracic Disease·Vesa ChengKiran Shekar

❮ Previous
Next ❯

Citations

Jul 9, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Dana BakdachIbrahim Hassan
Feb 5, 2021·Expert Review of Medical Devices·Christopher GaisendreesThorsten Wahlers
Apr 23, 2021·The Annals of Pharmacotherapy·Diane DreuceanKevin R Donahue
May 14, 2021·The International Journal of Artificial Organs·Kelsey L BrowderKomal A Pandya

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation

Software Mentioned

Anaconda©
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University
W L TangX W Jiang
Medicina clínica
Miguel Lozano, Roberto Mazzara
The New England Journal of Medicine
J L Chin
© 2022 Meta ULC. All rights reserved