Propofol concentration required for endotracheal intubation with a laryngoscope or fiberscope and its interaction with fentanyl

Anesthesia and Analgesia
T KazamaM Kikura

Abstract

The administration of fentanyl with propofol reduces the blood concentration of propofol required to achieve adequate anesthesia for tracheal intubation. However, different intubation procedures have variable intensities of noxious stimulation and may require different levels of anesthesia. The goal of this study was to determine the propofol blood concentration at which 50% of patients did not respond to stimulation (Cp50) for laryngoscopy, intubation with a laryngoscope, insertion of a slotted oral-pharyngeal airway (Ovassapian airway), and intubation with a fiberscope when administered in conjunction with fentanyl. Patients undergoing elective surgery were given varying amounts of propofol or propofol with fentanyl, and their responses to the four procedures listed above were assessed. These experiments demonstrated that the propofol concentration required for intubation with a laryngoscope was similar to that for intubation with a fiberscope, and that the required level was reduced by fentanyl. Hemodynamic responses to intubation were lower with a fiberscope than with a laryngoscope. We conclude that almost the same concentrations of propofol or fentanyl are necessary for suppressing both of the somatic responses to trachea...Continue Reading

References

Oct 1, 1977·Anesthesiology·R W YakaitisJ P Angiulo
Jan 1, 1988·Anaesthesia·B E Smith, D Siggins
Sep 1, 1987·British Journal of Anaesthesia·K M VermeyenG H Hanegreefs
Feb 1, 1973·Anesthesiology·I W CarsonT G McNabb
May 1, 1993·Anesthesiology·A I McEwanP S Glass

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Citations

Feb 19, 2002·Paediatric Anaesthesia·Lionel SimonAnne-Marie Dubousset
Aug 24, 2012·Veterinary Surgery : VS·Pieter NelissenRichard A S White
May 4, 2004·Annales Françaises D'anesthèsie Et De Rèanimation·X Viviand, F Garnier
Jan 11, 2000·Emergency Medicine Clinics of North America·P S Wadbrook
Nov 8, 2006·European Journal of Anaesthesiology·G GueretJ-L Bourgain
Jun 7, 2003·European Journal of Anaesthesiology·H SchwildenJ Schüttler
Jul 30, 2004·Anesthesia and Analgesia·Masanori KashiwagiJunzo Takeda

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