Propofol formulated with long-/medium-chain triglycerides reduces the pain of injection by target controlled infusion

Acta Anaesthesiologica Scandinavica
H SuzukiY Yamada

Abstract

Propofol is a widely used intravenous anesthetic although its injection pain is a common and unpleasant problem. Long-/medium-chain triglyceride (LCT/MCT) propofol has been introduced, as its low free propofol content is expected to reduce injection pain compared with LCT propofol. Target controlled infusion (TCI) differs from conventional induction in the initial infusion pattern. During induction using TCI, we investigated injection pain caused by two propofol solutions with different triglyceride compositions. Fifty patients, ASA I-II, with adequate communicative ability, were randomly assigned to two groups. TCI was conducted with Diprifusor for LCT and with BeComSim (custom-made software) for LCT/MCT. The target blood concentration was set at 4 microg/ml for both groups. At 30, 60, and 120 s after the infusion, patients were asked questions regarding the severity of pain on a 0-10 pain score. The total dose of propofol and the time required to induce anesthesia were also investigated. The LCT/MCT propofol group had a larger number of pain-free patients and showed lower severity of pain than the LCT group [the number of pain-free patients being 11 and 3, respectively (P < 0.05), and median maximum pain being 0 and 4.5, resp...Continue Reading

References

Sep 1, 1991·British Journal of Anaesthesia·W Klement, J O Arndt
Mar 1, 1996·Anesthesia and Analgesia·A W DoenickeJ Babl
Dec 9, 1997·Anesthesia and Analgesia·A W DoenickeJ Babl
Mar 29, 2000·Anesthesia and Analgesia·P Picard, M R Tramèr
Jul 28, 2001·Anesthesia and Analgesia·J RauU Strohschneider
Sep 7, 2004·British Journal of Anaesthesia·J R Sneyd
Feb 18, 2005·Acta Anaesthesiologica Scandinavica·E Liljeroth, J Akeson

❮ Previous
Next ❯

Citations

Jul 11, 2007·Current Opinion in Anaesthesiology·Haibo WangAshock Rao
Apr 19, 2008·Acta Anaesthesiologica Scandinavica·J Akeson
Feb 18, 2009·British Journal of Clinical Pharmacology·Ji-Yeon SimGyu-Jeong Noh
Mar 24, 2007·Acta Anaesthesiologica Scandinavica·E LiljerothJ Akeson
Dec 17, 2009·Acta Anaesthesiologica Scandinavica·J A AldreteD Quiroga
Jul 11, 2007·Current Opinion in Anaesthesiology
Jul 4, 2012·Revista española de anestesiología y reanimación·S TelletxeaL F Ortega

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.