Propofol-induced alpha rhythm

Neuropsychobiology
V A FeshchenkoR A Reinsel

Abstract

The electroencephalographic effects of two intravenous sedative/hypnotic drugs, propofol and thiopental, were studied at three stable blood concentrations in 52 normal healthy volunteers. The higher concentration resulted in unresponsiveness (lack of response to auditory/tactile stimuli) in all subjects. This report describes the strong frontal-central rhythms apparent in this state using a quantitative description of oscillatory systems underlying the rhythm. These rhythms occur when sedative drug concentrations are greater than those producing the well-described increase in broadband beta-power associated with many sedative drugs. Propofol induces rhythms in the alpha-range, while thiopental produces rhythms in the beta-range. Quasistationary for a period of about 1 h, these rhythms exceed the baseline alpha-rhythm in power. By their resonant nature, these propofol-induced rhythms are analogous to 'the classic alpha-rhythm', but quantitative characteristics of the underlying oscillatory systems are different. Baseline properties of the oscillatory system underlying the initial resting alpha-rhythm recover completely as drug concentration decays to negligible values.

Associated Clinical Trials

Citations

Nov 13, 2008·Cognitive Neurodynamics·Brett L FosterDavid T J Liley
May 21, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Vadim V NikulinSeppo Kähkönen
Dec 31, 2010·The New England Journal of Medicine·Emery N BrownNicholas D Schiff
May 11, 2011·Proceedings of the National Academy of Sciences of the United States of America·Aylin CimenserEmery N Brown
Dec 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Shinung ChingNancy J Kopell
Nov 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Laura D LewisPatrick L Purdon
Jul 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sujith VijayanNancy J Kopell
Mar 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Patrick L PurdonEmery N Brown
Nov 28, 2014·Journal of Pharmacological Sciences·Yi ZhangTian Yu
Sep 13, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Brett L Foster, David T J Liley
Mar 8, 2012·NeuroImage·Rikkert Hindriks, Michel J A M van Putten
Jun 30, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Kara J PavoneEmery N Brown
Jan 15, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Daniel San-juanAndrew J Cole
Sep 25, 2015·Journal of Cognitive Neuroscience·Nicole C SwannPhilip A Starr
Oct 7, 2015·Frontiers in Neural Circuits·Andrew Y Y Tan
Aug 19, 2015·Anesthesiology·Patrick L PurdonEmery N Brown
Jan 25, 2014·Current Opinion in Neurobiology·Shinung Ching, Emery N Brown
May 15, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Oluwaseun AkejuEmery N Brown
Jul 16, 2015·British Journal of Anaesthesia·R A Veselis
Jul 16, 2015·British Journal of Anaesthesia·O AkejuP L Purdon
Jul 30, 2014·Frontiers in Systems Neuroscience·Stefanie Blain-MoraesGeorge A Mashour
Dec 30, 2014·Frontiers in Systems Neuroscience·Meysam HashemiJamie Sleigh
Oct 9, 2014·Anesthesiology·Stefanie Blain-MoraesGeorge A Mashour
Sep 19, 2014·Anesthesiology·Oluwaseun AkejuPatrick L Purdon
Jul 22, 2018·Anesthesiology·Lynn UhrigBechir Jarraya
Jan 10, 2019·Journal of Neurophysiology·Paulo Vianney-RodriguesRichard Salvi
Sep 21, 2013·Journal of Neurophysiology·Kristin K SellersFlavio Fröhlich
Jan 20, 2018·Journal of Dental Anesthesia and Pain Medicine·Byung-Moon Choi
Oct 21, 2016·Anesthesia and Analgesia·Anthony G Hudetz, George A Mashour

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.