Propofol-induced priapism, a case confirmed with rechallenge

The Annals of Pharmacotherapy
Kimi S VestaEllen A Kozlowski

Abstract

To report a case of propofol-induced priapism. A 17-year-old male receiving propofol for induction of anesthesia during a cardiac ablation procedure developed priapism that required medical intervention and discontinuation of propofol. The priapism developed after a total propofol dose of 550 mg, lasted for 2 hours, and resolved immediately following medical intervention. The following day, the patient underwent a transesophageal echocardiogram and received a total propofol dose of 40 mg throughout the procedure. He again developed priapism, which resolved within one hour without medical intervention. Priapism experienced by this patient is considered to be drug-induced because of the temporal relationship, recurrence with rechallenge, and dose-response relationship. Using the Naranjo probability scale, we determined that propofol was a highly probable causative agent of priapism in this patient. Although, as of April 4, 2006, this adverse effect has not been previously reported, there is a strong correlation of propofol to priapism in this patient. Clinicians should be aware of this adverse effect.

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Citations

Oct 12, 2010·Indian Journal of Pharmacology·Subramanian SenthilkumaranPonniah Thirumalaikolundusubramanian
Aug 2, 2011·Medical Hypotheses·Shah SweniPonniah Thirumalaikolundusubramanian
Jun 2, 2017·BMJ Case Reports·Bartholomeus J G A CortenJeroen Vogelaar
Dec 20, 2007·International Clinical Psychopharmacology·Shabnam SoodMaria-Jesus Bailon
Jul 10, 2019·Global Pediatric Health·Cody SavoieParas Khandhar
Feb 9, 2021·The American Journal of Emergency Medicine·Matthew L SilvermanThomas J Donnelly
Aug 1, 2020·The American Journal of Emergency Medicine·Myriam LamamriStéphane Legriel

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