Abstract
This study investigated the effects of propofol on gastric cancer MKN45 cell proliferation, migration, invasion and apoptosis, as well as underlying potential mechanisms. The viability, proliferation, apoptosis, migration and invasion of MKN45 cells were assessed using CCK-8 assay, BrdU incorporation assay, Annexin V-FITC/PI staining, two-chamber migration (invasion) assay and western blotting, respectively. qRT-PCR was performed to measure the expression of microRNA-195 (miR-195). Cell transfection was conducted to down-regulate the expression of miR-195. Propofol treatment suppressed MKN45 cell proliferation, migration and invasion, but promoted cell apoptosis. The expression of miR-195 was increased after propofol treatment. Suppression of miR-195 reversed the propofol-induced MKN45 cell proliferation, migration and invasion inhibition, as well as apoptosis. Moreover, Propofol treatment inactivated JAK/STAT and NF-κB pathways in MKN45 cells. Suppression of miR-195 reversed the propofol-induced inactivation of JAK/STAT and NF-κB pathways. Inhibition of JAK/STAT and NF-κB pathways reversed the effects of miR-195 suppression on propofol-induced MKN 45 cell proliferation, migration and invasion inhibition, as well as apoptosis e...Continue Reading
References
Aug 1, 1990·Clinical Pharmacokinetics·B M Frey, F J Frey
Sep 20, 2005·Breast Cancer Research : BCR·Rafat A SiddiquiWilliam Stillwell
Nov 17, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kiyonori KurikiKazuo Tajima
Oct 21, 2009·Progress in Molecular and Subcellular Biology·Marc R FabianNahum Sonenberg
Nov 6, 2009·British Journal of Cancer·M YaghoobiS A Narod
Mar 20, 2010·Methods in Molecular Biology·Shahar Ish-Shalom, Amnon Lichter
Oct 12, 2010·Saudi Journal of Anaesthesia·Sukhminder Jit Singh BajwaJasbir Kaur
Apr 17, 2012·Integrative Cancer Therapies·Jeong Won HwangIk-Soon Jang
Oct 16, 2012·Drugs·Lily P H Yang, Gillian M Keating
Jan 16, 2013·Cell Biology International·Jian ZhangSheng-mei Zhu
Jan 22, 2013·Gene·Hongxia DengJunming Guo
May 15, 2013·International Journal of Molecular Medicine·Zhaofeng ChenLiang Qiao
Oct 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T WaddellUNKNOWN European Society of Radiotherapy and Oncology (ESTRO)
Nov 8, 2013·Molecular Biology Reports·Sami UllahAttya Bhatti
Feb 11, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wen-Yao CuiQiu-Shi Wang
Aug 12, 2014·JAK-STAT·Jayant ShravahDavid M Ansley
Oct 9, 2014·Journal of Translational Medicine·Jian ZhangSheng-mei Zhu
May 17, 2015·Advanced Drug Delivery Reviews·Scott M Hammond
Jul 5, 2015·Pediatric Rheumatology Online Journal·Amit Oren-ZivYosef Uziel
Jul 28, 2015·Genetics and Molecular Research : GMR·Z T WangT L Dong
Aug 21, 2015·CNS Drugs·Vidya ChidambaranAjay D'Mello
Sep 18, 2015·Journal of Translational Medicine·Agata AbramowiczPiotr Widlak
Feb 14, 2016·European Journal of Nutrition·Yao YeDajing Xia
Mar 17, 2016·European Journal of Anaesthesiology·Felix UlbrichNils Schallner
May 3, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yilin WangLihui Lai
May 14, 2016·Genetics and Molecular Research : GMR·Z Peng, Y Zhang
Jun 29, 2016·Cytokine·Jan PencikLukas Kenner
Nov 15, 2016·Oncology Reports·Cheng YangJiamin Liang
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 31, 2017·Oncology Letters·Alessandro MorottiGiuseppe Saglio
Aug 30, 2017·GE Portuguese Journal of Gastroenterology·Pedro Pimentel-NunesMário Dinis-Ribeiro
Jan 11, 2018·Methods in Molecular Biology·Zoi PiperigkouAchilleas D Theocharis
Feb 1, 2018·Oncotarget·Puja KhannaGyeong Hun Baeg
Citations
Mar 13, 2019·Basic & Clinical Pharmacology & Toxicology·Xiangdi YuFangxiang Zhang
Jul 12, 2019·Anesthesia and Analgesia·Juan P CataPer-Arne Lonnqvist
Oct 29, 2019·Current Cancer Drug Targets·Milad AshrafizadehSaeed Samarghandian
Dec 14, 2018·Experimental and Therapeutic Medicine·Wei CaoTiejun Liu
Jul 29, 2020·Cancer Communications·Meng ZhaoLi Ren
Jun 23, 2020·Oncology Letters·Hao WangSongpo Wang
Aug 29, 2020·Cell Cycle·Huaping ZhaoJianjun Yang
Aug 27, 2018·Journal of Cellular Biochemistry·Peiqi WanDavid A Geller
Sep 24, 2020·Phytotherapy Research : PTR·Yue GaoXianli Meng
Jan 3, 2020·Biotechnology Letters·Yujin LiGaopeng Xiao
Dec 20, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Yan ZhangZhi Lan
Jul 1, 2020·Cell Proliferation·Yichi XuXueqiong Zhu
Apr 24, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yan-Ling Ren, Wei Zhang
Sep 21, 2019·Journal of Cellular Physiology·Yan Sun, Hai Sun
Nov 20, 2019·Anesthesia and Analgesia·Juan P CataPer-Arne Lonnqvist
Sep 13, 2020·Journal of Ethnopharmacology·Chen ChenYu-Hui Wei
Oct 27, 2020·Anesthesia and Analgesia·Chun-Yu ChangMing-Chang Kao
Dec 21, 2018·International Journal of Biological Macromolecules·Lizhou JiaZhenqing Feng
Mar 28, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Z M BaiL L Tang
Apr 6, 2021·International Immunopharmacology·Hong WangShanshan Li
May 7, 2021·Pharmacogenomics and Personalized Medicine·Hao WangZhen-Tao Yu
Apr 25, 2021·Biotechnology and Applied Biochemistry·Chen CaoYi Xu
May 29, 2021·Acta histochemica·Su-Hong TanYuan Li
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bing YanDesheng Yang
Aug 12, 2021·Cancer Management and Research·Leyi LiuJun Sheng
Sep 13, 2021·FEBS Open Bio·Yu OtaMasakazu Haneda
Mar 9, 2019·Experimental and Molecular Pathology·Chong WangZhaochuan Yang