Propofol or midazolam for sedation and early extubation following cardiac surgery

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
N R SearleD Lussier

Abstract

The purpose of this randomized, double-blind study was to evaluate the efficacy of midazolam and propofol for postoperative sedation and early extubation following cardiac surgery. ASA physical status II-III patients scheduled to undergo elective first-time cardiac surgery with an ejection fraction > 45% were eligible. All patients received a standardized sufentanil/isoflurane anaesthesia. During cardiopulmonary bypass 100 micrograms.kg-1.min-1 propofol was substituted for isoflurane. Upon arrival in the Intensive Care Unit (ICU), patients were randomized to either 10 micrograms.kg-1.min-1 propofol (n = 21) or 0.25 microgram.kg-1.min-1 midazolam (n = 20). Infusion rates were adjusted to maintain sedation within a predetermined range (Ramsay 2-4). The infusion was terminated after four hours. Patients were weaned from mechanical ventilation and their tracheas extubated when Haemodynamic stability, haemostasis, normothermia and mental orientation were confirmed. Haemodynamic measurements, arterial blood gas tensions and pulmonary function tests were recorded at specified times. There were no differences between the two groups for the time spent at each level of sedation, number of infusion rate adjustments, amount of analgesic an...Continue Reading

References

Oct 1, 1990·British Journal of Anaesthesia·N J MasseyJ E Peacock
Feb 14, 1987·British Medical Journal·R M GroundsM Morgan
May 1, 1987·British Journal of Anaesthesia·H M MathewsI A Orr
Jun 1, 1987·Anaesthesia·M P ShellyG R Park
Jun 22, 1974·British Medical Journal·M A RamsayR Goodwin
Sep 1, 1994·British Journal of Anaesthesia·S M GeddesA J Asbury
Dec 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R I Hall

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Citations

Aug 24, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Dominique A BettexEdith R Schmid
Jan 5, 2000·The Annals of Thoracic Surgery·R AscioneG D Angelini
Feb 6, 2002·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·UNKNOWN American College of Critical Care Medicine of the Society of Critical Care Medicine, American Society of Health-System Pharm
Feb 26, 2003·PharmacoEconomics·Prabashni Reddy, Jessica Song
Feb 21, 2002·Journal of Cardiothoracic and Vascular Anesthesia·Stewart E MilneStephen Hickey
Jun 19, 2013·Medicina intensiva·E Celis-RodríguezUNKNOWN Federación Panamericana e Ibérica de Sociedades de Medicina Crítica y Terapia Intensiva
Sep 21, 2010·Journal of Cardiothoracic and Vascular Anesthesia·William C OliverMartin D Abel
Jan 25, 2002·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·J M Magarey
Jan 24, 2006·Journal of Clinical Anesthesia·Yuji KadoiFumio Goto
Dec 6, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Gurkan TurkerErkan Sayan
Jan 5, 2002·Critical Care Clinics·E T Wittbrodt
Oct 6, 2006·Expert Opinion on Pharmacotherapy·Robert MacLaren, Patrick W Sullivan
Mar 22, 2008·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Sandeep NayakJeff Carson
Dec 28, 2012·Critical Care Medicine·Juliana BarrUNKNOWN American College of Critical Care Medicine
Dec 26, 2001·Anesthesiology·Aslam H AnisUNKNOWN Propofol Study Group
Feb 18, 2017·Journal of Physical Therapy Science·Kouji YamashitaYoshihiro Takeyama
Mar 21, 2002·Critical Care Medicine·Judith JacobiUNKNOWN Task Force of the American College of Critical Care Medicine (ACCM) of the Society of Critical Care Medicine (SCCM), America

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