Propofol reduces nitric oxide-induced apoptosis in testicular ischemia-reperfusion injury by downregulating the expression of inducible nitric oxide synthase

Acta Anaesthesiologica Scandinavica
H YagmurdurC Germiyanoglu

Abstract

The aim of the present study was to investigate the underlying mechanisms in the preventive effects of intravenous anesthetics on testicular ischemia-reperfusion injury. Forty male Wistar Albino rats were randomly assigned to four groups of 10 rats each. Anesthesia was induced and maintained with thiopental in groups 1 and 2 and with propofol in groups 3 and 4. Groups 2 and 4 received left testicular ischemia (torsion) for 1 h and reperfusion (detorsion) for 24 h. Groups 1 and 3 (control groups) had no testicular torsion and detorsion. At 24 h of reperfusion, animals were killed and ipsilateral testes were removed for determination of tissue nitric oxide (NO) levels and immunohistochemical evaluation of endothelial nitric oxide synthase (eNOS), inducible NOS (iNOS), and apoptosis protease-activating factor 1 (APAF-1). Between groups 1 and 3, there were no differences in tissue NO levels and eNOS, iNOS, and APAF-1 expressions. iNOS and APAF-1 expressions were markedly increased in group 2, but these parameters were at the mild to moderate level in group 4 at 24 h of reperfusion. Also, elevated expression of iNOS was accompanied by a high NO production in group 2 compared with group 4. Although eNOS expressions were increased in ...Continue Reading

References

Jun 1, 1992·British Journal of Anaesthesia·P G MurphyJ G Jones
Aug 1, 1991·Archives of Biochemistry and Biophysics·R RadiB A Freeman
Dec 21, 1991·Lancet·S MidgleyD J Webb
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Jan 4, 1998·Biology of Reproduction·T T TurnerL W Wilson
Aug 6, 1998·British Journal of Anaesthesia·A T DemiryürekI Kanzik
Nov 4, 1998·Free Radical Biology & Medicine·M G BlaylockN R Webster
Jun 3, 2000·Nitric Oxide : Biology and Chemistry·M Cudic, C Ducrocq
May 2, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Hang ChangRuei-Ming Chen
Aug 29, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Amiya P Sinha HikimRonald S Swerdloff
Mar 31, 2004·Molecular Aspects of Medicine·Danilo Wilhelm FilhoAlberto Boveris
Jun 3, 2004·Life Sciences·Fugen Aktan
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
Oct 28, 2006·Acta Anaesthesiologica Scandinavica·H YagmurdurC Germiyanoglu
Nov 24, 2006·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J GaoZ Q Chen

❮ Previous
Next ❯

Citations

Sep 11, 2012·Pediatric Surgery International·Latif AbbasoğluMüjdat Uysal
Jan 14, 2010·Journal of Anesthesia·Bayazit DikmenCankon Germiyanoglu
Aug 10, 2011·Clinical and Experimental Pharmacology & Physiology·Wen-Yao CuiTao Bai
Jun 18, 2014·Nature Reviews. Urology·Ersagun KaraguzelOmer Kutlu
Apr 8, 2010·Renal Failure·Zafer DoganErtan Bülbüloglu
Feb 7, 2013·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Yu-Chuan TsaiYen-Chin Liu
Mar 8, 2016·Life Sciences·Wenguo FanHongwen He
Apr 7, 2012·Life Sciences·Panagiota TsounapiKeisuke Satoh
Jul 25, 2009·Anesthesiology·Luca Siracusano, Viviana Girasole
Mar 2, 2012·Acta Cirúrgica Brasileira·Antônio Urt FilhoCarlos Henrique Marques dos Santos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis