Propofol restores brain microvascular function impaired by high glucose via the decrease in oxidative stress

Anesthesiology
Katsutoshi NakahataYoshio Hatano

Abstract

Vascular dysfunction induced by hyperglycemia has not been studied in cerebral parenchymal circulation. The current study was designed to examine whether high glucose impairs dilation of cerebral parenchymal arterioles via nitric oxide synthase, and whether propofol recovers this vasodilation by reducing superoxide levels in the brain. Cerebral parenchymal arterioles in the rat brain slices were monitored using computer-assisted videomicroscopy. Vasodilation induced by acetylcholine (10 to 10 m) was obtained after the incubation of brain slices for 60 min with any addition of l-glucose (20 mm), d-glucose (20 mm), or propofol (3 x 10 or 10 m) in combination with d-glucose (20 mm). Superoxide production in the brain slice was determined by dihydroethidium (2 x 10 m) fluorescence. Addition of d-glucose, but not l-glucose, reduced arteriolar dilation by acetylcholine, whereas the dilation was abolished by the neuronal nitric oxide synthase inhibitor S-methyl-l-thiocitrulline (10 m). Both propofol and the superoxide dismutase mimetic Tempol (10 m) restored the arteriolar dilation in response to acetylcholine in the brain slice treated with d-glucose. Addition of d-glucose increased superoxide production in the brain slice, whereas p...Continue Reading

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Citations

Nov 18, 2011·Journal of Anesthesia·Hiroyuki Kinoshita
Nov 26, 2010·Cell Biochemistry and Biophysics·Zhiqiang XuJuan Liu
Dec 21, 2011·Journal of Neurotrauma·Michèle TanguyYannick Malledant
Jun 28, 2011·Arhiv za higijenu rada i toksikologiju·Hülya TürkanBensu Karahalil
Apr 9, 2008·Free Radical Biology & Medicine·Irwin Fridovich
Mar 19, 2016·Cellular and Molecular Neurobiology·T Michael De Silva, Frank M Faraci
Sep 13, 2014·Diabetes & Metabolism Journal·Shekoufeh BehdadSaidhossein Khalilzadeh
Sep 2, 2019·Journal of Anesthesia·Tomohiro ChakiMichiaki Yamakage

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