Propofol suppresses activation of the nociception specific neuron in the parafascicular nucleus of the thalamus evoked by coronary artery occlusion in rats

European Journal of Anaesthesiology
Jin Ping Wang, Zheng Guo

Abstract

The neural response to acute myocardial ischaemia was reported as increases in neuronal activity of spinal projecting neurons and the neurons in the parafascicular nucleus (Pf) of the thalamus. The aim of this study was to investigate electrophysiologically the response of the nociception specific neuron (NSN) in the Pf to coronary artery occlusion (CAO) and a potential antinociceptive effect of propofol on the response in rats. The left anterior descending branch of the coronary artery was instrumented with a snare occluder in anaesthetized Sprague-Dawley rats. The unit discharges of the NSN were recorded using a single-barrel glass microelectrode and analysed to examine the response to CAO. Once the effect of CAO on the discharge was detected, the antinociceptive effect of propofol was examined. The NSN (30/46) showed a significant increase in the discharge rate following CAO. The increased discharge was suppressed immediately after intravenous injection of propofol at doses of 0.2 and 2 mgkg(-1). The inhibitory effect reached the maximum at 7 min (59.78 +/- 11.17% of suppression, P < 0.05) and 5 min (95.21 +/- 4.79% of suppression, P < 0.05) following administration of 0.2 and 2 mgkg(-1) of propofol, respectively. The effect...Continue Reading

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Citations

Jan 9, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Antigona HasaniHysni Jashari
Jun 11, 2011·European Journal of Anaesthesiology·Argyro Fassoulaki
Jan 10, 2012·Journal of Transcultural Nursing : Official Journal of the Transcultural Nursing Society·Nadiye OzerRahşan Çevik Akyil
Nov 22, 2019·Comprehensive Child and Adolescent Nursing·Tuba ArpaciMehmet Gunduz
May 7, 2020·Journal of Neuroscience Methods·Li FanHongbing Xiang

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