Propofol versus traditional sedative agents for advanced endoscopic procedures: a meta-analysis

Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society
Saurabh SethiMandeep S Sawhney

Abstract

The optimum method for sedation for advanced endoscopic procedures is not known. Propofol deep sedation has a faster recovery time than traditional sedative agents, but may be associated with increased complication rates. The aim of the present study was to pool data from all available studies to systematically compare the efficacy and safety of propofol with traditional sedative agents for advanced endoscopic procedures. Databases including PubMed, Embase, Web of Science and the Cochrane Central Register of Controlled Trials updated as of January 2013 were searched. Main outcome measures were procedure duration, recovery time, incidence of complications (hypotension, hypoxia), sedation level, patient cooperation and amnesia during advanced endoscopic procedures such as endoscopic retrograde cholangiopancreatography, endoscopic ultrasonography, and deep small bowel enteroscopy. Nine prospective randomized trials with a total of 969 patients (485 propofol, 484 conscious sedation) were included in the meta-analysis. Pooled mean difference in procedure duration between propofol and traditional sedative agents was -2.3 min [95% CI: -6.36 to 1.76, P = 0.27], showing no significant difference in procedure duration between the two gro...Continue Reading

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Citations

Feb 26, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Enrique Pérez-Cuadrado RoblesLeopoldo López Roses
Dec 24, 2015·Gut and Liver·Chang Kyun LeeUNKNOWN Korean Society of Gastrointestinal Endoscopy Task Force on Endoscopic Sedation
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Mar 10, 2018·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Minmin XueDongxu Wang
Feb 10, 2018·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Sauid IshaqHelmut Neumann
Jul 27, 2018·Frontline Gastroenterology·Hey-Long ChingReena Sidhu
Nov 14, 2015·Journal of Clinical Gastroenterology·Francis C OkekeAlan S Rosman
Apr 6, 2018·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Enrique Pérez-Cuadrado-RoblesJesús García-Cano
Oct 16, 2018·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Laura Julián GómezSantiago José Rodríguez Gómez
Dec 17, 2019·World Journal of Gastrointestinal Endoscopy·Aureo Augusto de Almeida DelgadoEduardo Guimarães Hourneaux de Moura
Feb 10, 2018·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Lara Luzón SolanasRafael Uribarrena Amezaga
Jul 20, 2018·United European Gastroenterology Journal·Toshihiro Nishizawa, Hidekazu Suzuki
Jun 4, 2019·European Journal of Hospital Pharmacy. Science and Practice·Yang YuJiake He
Oct 31, 2020·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Takuji GotodaHaruhiro Inoue

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