Propofol vs midazolam plus fentanyl for upper gastrointestinal endomicroscopy: a randomized trial.

World Journal of Gastroenterology : WJG
Xiu-Li ZuoYan-Qing Li

Abstract

To compare the endomicroscopic image quality of integrated confocal laser endomicroscopy (iCLE) and sedation efficacy of propofol vs midazolam plus fentanyl (M/F). Consecutive outpatients undergoing iCLE were prospectively recruited and randomized to the propofol group (P group) or M/F group. The patient, performing endoscopist and endoscopic assistant were blinded to the randomization. The quality of endomicroscopic images and anesthetic efficacy outcomes were blindly evaluated after iCLE examination. There were significantly more good quality endomicroscopic images in the propofol group than in the M/F group (72.75% vs 52.89%, P < 0.001). The diagnostic accuracy for upper gastrointestinal mucosal lesions using confocal laser endomicroscopy favors the P group, although this did not reach statistical significance. Adverse events and patient assessment were not significantly different for M/F vs propofol except for more frequent intraprocedural recall with M/F. Procedure duration and sedation times were significantly longer in the M/F group, while the scores of endoscopist, anesthetist and assistant assessment were all significantly better in the P group. Sedation with propofol might increase the proportion of good quality endom...Continue Reading

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Citations

Oct 20, 2012·World Journal of Gastroenterology : WJG·Ludwig T HeussChristoph Beglinger
Jan 23, 2013·Journal of Digestive Diseases·Chao LiuYan Qing Li
Jul 5, 2012·Current Opinion in Gastroenterology·John I Allen
Dec 17, 2019·World Journal of Gastrointestinal Endoscopy·Aureo Augusto de Almeida DelgadoEduardo Guimarães Hourneaux de Moura
Feb 18, 2020·World Journal of Gastroenterology : WJG·Jun-Liang TehJimmy Bok-Yan So
Oct 8, 2019·Journal of Vascular and Interventional Radiology : JVIR·Barbara ManchecThomas J Ward
Aug 29, 2020·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Patrick CherfanEfthymios D Avgerinos

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