Propolis ethanolic extracts reduce adenosine diphosphate induced platelet aggregation determined on whole blood

Nutrition Journal
Mirza BojićŽeljan Maleš

Abstract

Propolis is a well-known bee product containing more than 2000 identified compounds. It has many beneficial effects on human health that include antibacterial, antiviral, anticancer and hepatoprotective justifying its use as a dietary supplement. Platelet aggregation plays crucial role in thrombus formation that can cause stroke or heart attacks. As cardiovascular diseases, including those caused by thrombus formation, are related to 50% of deaths of Western population, the objective of this study was to determine antiaggregatory activity of propolis on platelet aggregation on the whole blood samples. Twenty one propolis samples from Southeast Europe were characterized by spectrophotometric methods to determine content of the total flavonoids and phenolic acids. High performance liquid chromatography coupled with diode array detection was used to identify and quantify individual polyphenols. Platelet aggregation was tested by impedance aggregometry on the whole blood samples of ten healthy volunteers. The mean content of total polyphenols was 136.14 mg/g and ranged from 59.23 to 277.39 mg/g. Content of total flavonoids ranged between 6.83 and 55.44 mg/g with the mean value of 19.28 mg/g. Percentage of total phenolic acids was i...Continue Reading

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Citations

Dec 28, 2019·International Journal of Molecular Sciences·Borkwei Ed NignpenseAbishek B Santhakumar
Sep 25, 2019·Archives of Gynecology and Obstetrics·Fatime GeyikogluYavuz Selim Saglam
Sep 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mirza BojićŽeljan Maleš
Jan 8, 2021·Biology·Henrique SilvaAntónio Raposo
Oct 23, 2019·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Mirza BojićMaja Tomičić
May 5, 2021·Journal of Natural Medicines·Chihiro SugitaMasahiko Kurokawa

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