Propolis extract release evaluation from topical formulations by chemiluminescence and HPLC.

Journal of Pharmaceutical and Biomedical Analysis
Franciane D MarqueleMaria J V Fonseca

Abstract

Propolis is a resinous bee hive product that has many biological activities. Among these activities, the antioxidant activity deserves special interest since it suggests propolis could be successfully applied topically to prevent and treat skin damages. The skin is continuously exposed to free radicals generated in the aging process and by external stimuli such as sunlight. Thus, the development of topical formulations added with propolis extract is justified. However, it raises the necessity of being concerned about the methodologies that could be used to evaluate the propolis extract release from these formulations. So, p-coumaric acid content using HPLC and the antioxidant activity using chemiluminescence were used to assess the release of propolis extract from topical formulations. A low fat content formulation (F1) and a high fat content formulation (F2) were evaluated and they showed that after 6 h, 4.6 microg/cm2 (F1) and 2.75 microg/cm2 (F2) of the p-coumaric acid was released, while it was found that both formulations released about 0.85 microL/cm2 of the antioxidant activity as propolis extract equivalent (AAPEE). Thus, once the antioxidant activity of propolis extract may be the result of the synergic action of sever...Continue Reading

References

Feb 15, 2005·Journal of Pharmaceutical and Biomedical Analysis·Valéria M Di Mambro, Maria J V Fonseca
Mar 3, 2005·Journal of Pharmaceutical and Biomedical Analysis·A Femenía-FontA López-Castellano

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Citations

Jun 15, 2013·International Journal of Cosmetic Science·O V ZillichM Kerscher
Feb 26, 2015·International Journal of Cosmetic Science·O V ZillichM Kerscher
Oct 19, 2010·Evidence-based Complementary and Alternative Medicine : ECAM·Yris Maria FonsecaMaria José Vieira Fonseca
Jun 14, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Modestas ZiliusVitalis Briedis
Apr 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Kristina RamanauskienėVitalis Briedis
May 3, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Selim ErdoganTurgay Seckin
Oct 21, 2009·Journal of Microencapsulation·Nick KalogeropoulosVaios T Karathanos
May 15, 2018·Critical Reviews in Analytical Chemistry·Paula Scanavez FerreiraMarlus Chorilli

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