PMID: 7538652Feb 13, 1995Paper

Proportion of NADPH-diaphorase reactive sympathetic efferents innervating the normal and inflamed knee joint of the cat

Neuroscience Letters
B Heppelmann, C Bscheidl

Abstract

To determine whether postganglionic sympathetic efferents may be a source of nitric oxide in normal and inflamed knee joints, the distribution of NADPH-diaphorase was studied in retrogradely labelled neurons of the paravertebral sympathetic ganglia in the cat. In these ganglia, a strong NADPH-diaphorase staining reaction was found in 3-7% (segments L2-L5) and 14-17% (segments L6 and L7) of the neurons. Only 2.5 +/- 1.2% (mean +/- SD, 4 normal joints), of 2207 labelled neurons showed a positive staining reaction. During a unilateral inflammation (32 h), this proportion slightly increased to 5.0 +/- 1.2% (unaffected joints of 4 animals, 2510 labelled perikarya) and 5.4 +/- 2.8% (inflamed joints of 4 animals, 2578 labelled perikarya). However, these increases only attained statistical significance between the values obtained from control animals and from the normal sides of animals with a monoarthritis. Thus, the data indicate that in the sympathetic innervation of the normal and inflamed knee in the cat, the release of nitric oxide has little or no importance.

References

Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B T HopeS R Vincent
May 1, 1983·The Anatomical Record·L A Langford, R F Schmidt
Oct 1, 1993·British Journal of Pharmacology·A IalentiM Di Rosa
Oct 1, 1993·Pain·Hans-Georg Schaible, Blair D Grubb

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Citations

Oct 6, 1998·Journal of the Autonomic Nervous System·J J McDougallR C Bray

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