Proportional Feedback Control of Energy Intake During Obesity Pharmacotherapy

Obesity
Kevin D HallBritta Göbel

Abstract

Obesity pharmacotherapies result in an exponential time course for energy intake whereby large early decreases dissipate over time. This pattern of declining drug efficacy to decrease energy intake results in a weight loss plateau within approximately 1 year. This study aimed to elucidate the physiology underlying the exponential decay of drug effects on energy intake. Placebo-subtracted energy intake time courses were examined during long-term obesity pharmacotherapy trials for 14 different drugs or drug combinations within the theoretical framework of a proportional feedback control system regulating human body weight. Assuming each obesity drug had a relatively constant effect on average energy intake and did not affect other model parameters, our model correctly predicted that long-term placebo-subtracted energy intake was linearly related to early reductions in energy intake according to a prespecified equation with no free parameters. The simple model explained about 70% of the variance between drug studies with respect to the long-term effects on energy intake, although a significant proportional bias was evident. The exponential decay over time of obesity pharmacotherapies to suppress energy intake can be interpreted as...Continue Reading

References

Feb 29, 2000·Archives of Family Medicine·J HauptmanK R Segal
Sep 19, 2001·JAMA : the Journal of the American Medical Association·A Wirth, J Krause
Jun 28, 2005·Drugs·Lisa L Ioannides-DemosJohn J McNeil
Nov 26, 2008·Endocrinology and Metabolism Clinics of North America·George A Bray
Jul 22, 2010·The New England Journal of Medicine·Steven R SmithUNKNOWN Behavioral Modification and Lorcaserin for Overweight and Obesity Management (BLOOM) Study Group
Sep 8, 2010·The New England Journal of Medicine·W Philip T JamesUNKNOWN SCOUT Investigators
Aug 17, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A AstrupUNKNOWN NN8022-1807 Investigators
Aug 30, 2011·Lancet·Kevin D HallBoyd A Swinburn
May 1, 2012·Annual Review of Nutrition·Kevin D Hall
Nov 30, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H SuplicyR Radominski
Jun 26, 2014·Obesity·Britta GöbelKevin D Hall
Jun 5, 2015·The American Journal of Clinical Nutrition·Arjun SanghviKevin D Hall

❮ Previous
Next ❯

Citations

Jun 5, 2020·Circulation. Cardiovascular Quality and Outcomes·Junxiu LiuUNKNOWN FOOD-PRICE (Policy Review and Intervention Cost-Effectiveness) Project
Nov 2, 2019·The Proceedings of the Nutrition Society·R James StubbsJoanna Michalowska
Feb 3, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·R James Stubbs, Jake Turicchi
Feb 3, 2021·Nature Medicine·R James Stubbs
Mar 5, 2021·Obesity Facts·R James StubbsUNKNOWN The EASO Obesity Management Task Force

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy
pharmacotherapies

Software Mentioned

Excel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The British Journal of Psychiatry : the Journal of Mental Science
Tracey BywaterRhiannon Tudor Edwards
International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
C J Gordon, J H Ferguson
International Journal of Obesity : Journal of the International Association for the Study of Obesity
N-C LiangT H Moran
© 2022 Meta ULC. All rights reserved