PMID: 9180128Jun 1, 1997Paper

Proportionate reversible decreases in systolic function and myocardial oxygen consumption after modest reductions in coronary flow: hibernation versus stunning

Journal of the American College of Cardiology
A J ShermanF J Klocke

Abstract

This study sought to determine whether modest short-term reductions in coronary flow can produce subsequent proportionate reductions in myocardial function and O2 consumption compatible with myocardial hibernation. Acute studies indicate that myocardial energy utilization can be downregulated during moderate flow reduction. Whether this apparently beneficial adjustment persists into the reperfusion period is unsettled because most postischemic contractile dysfunction has been presumed to represent stunned or irreversibly injured myocardium. Responses of regional myocardial function and O2 consumption were assessed in chronically instrumented dogs after approximately 50% reductions in flow for 2 h (n = 8) or repeated 2-min total coronary occlusions (n = 6). When unrestricted perfusion was restored after sustained partial occlusions, regional function and O2 consumption stabilized at proportionate, systematically decreased levels ([mean +/- SEM] 80 +/- 3.1% and 81 +/- 5.1% of control values, both p < 0.05) and then returned to control values within 24 h. Similar proportionate reductions occurred after as few as five cycles of brief total occlusion (79 +/- 5.1% and 83 +/- 1.6% of control values, both again p < 0.05); these persist...Continue Reading

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Citations

Jul 11, 2000·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·K F KofoedH Kelbaek
Mar 18, 1999·The American Journal of Cardiology·S Iskander, A E Iskandrian
Nov 26, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Gerd HeuschShahbudin H Rahimtoola
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R SchulzG Heusch
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A J ShermanD B Evans
Oct 28, 1998·Physiological Reviews·G Heusch
Apr 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S LeeH Suga
Jul 17, 1999·The American Journal of Physiology·J M Canty, J A Fallavollita
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Robert S DeckerFrancis J Klocke

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