Proposal of COVID-19 Clinical Risk Score for the management of suspected COVID-19 cases: a case control study

BMC Infectious Diseases
Sho NakakuboSatoshi Konno

Abstract

No clinical scoring system has yet been established to estimate the likelihood of coronavirus disease (COVID-19) and determine the suitability of diagnostic testing in suspected COVID-19 patients. This was a single-center, retrospective, observational study of patients with suspected COVID-19 and confirmed COVID-19. Patient background, clinical course, laboratory and computed tomography (CT) findings, and the presence of alternative diagnoses were evaluated. Clinical risk scores were developed based on clinical differences between patients with and without COVID-19. Among 110 patients suspected of having COVID-19, 60.9% underwent polymerase chain reaction (PCR) testing based on the judgment of physicians. Two patients were found to have COVID-19. The clinical characteristics of 108 non-COVID-19 patients were compared with those of 23 confirmed COVID-19 patients. Patients with COVID-19 were more likely to have a history of high-risk exposures and an abnormal sense of taste and smell. The COVID-19 group had significantly higher rates of subnormal white blood cell counts, lower eosinophil counts, and lower procalcitonin levels than the non-COVID-19 group. When blood test results, CT findings, and the presence of alternative diagno...Continue Reading

References

Jan 13, 2006·JAMA : the Journal of the American Medical Association·Arne van BelleUNKNOWN Christopher Study Investigators
Feb 28, 2020·The Lancet Infectious Diseases·Heshui ShiChuansheng Zheng
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 1, 2020·International Journal of Surgery·Catrin SohrabiRiaz Agha
Mar 8, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Giuseppe Lippi, Mario Plebani
Mar 13, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chuan QinDai-Shi Tian
Mar 17, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Fang LiuJun Zhang
Apr 8, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jerome R LechienSven Saussez
Apr 29, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Fang LiuXiang Zhou
May 2, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jan C LuersLudwig M Heindl
May 14, 2020·BMJ : British Medical Journal·Jessica WatsonJohn E Brush
May 20, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Marlene M SpethAhmad R Sedaghat
Jun 6, 2020·The New England Journal of Medicine·Steven WoloshinAaron S Kesselheim
Jun 7, 2020·The Journal of Infection·Sumio IwasakiTakanori Teshima
Jun 23, 2020·Annals of Translational Medicine·Qi ZhouUNKNOWN COVID-19 Evidence and Recommendations Working Group
Jun 25, 2020·The Journal of Infection·Takeshi HattoriSatoshi Konno
Jul 1, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Tatsuya FukumotoTakanori Teshima
Aug 5, 2020·European Journal of Medical Research·Sulmaz GhahramaniFariba Ahmadizar

❮ Previous
Next ❯

Citations

Jun 20, 2021·Archives of public health = Archives belges de santé publique·Médéa LocquetAnne-Françoise Donneau

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

JMP
Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.